Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALPL | P05186 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | MTOR | P42345 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25886719 | 0.78 | ALPL (0.44) | ALPLALDH1A1MAPTNPSR1LMNA | |
| SCHEMBL30989718 | 0.78 | ALPL (0.44) | ALPLALDH1A1MAPTNPSR1LMNA | |
| SCHEMBL28274692 | 0.75 | TSHR (0.50) | ALDH1A1MAPTRAB9ANPSR1MTOR | |
| SCHEMBL10972259 | 0.74 | MAPT (0.49) | ALDH1A1MAPTMTORHPGDLMNA | |
| SCHEMBL2414267 | 0.74 | CA1 (0.50) | ALDH1A1MAPTRAB9ANPSR1MTOR | |
| SCHEMBL10288674 | 0.73 | ALPL (0.70) | ALPLMAPTKMT2ANPC1 | |
| SCHEMBL1960956 | 0.73 | KMT2A (0.45) | ALPLALDH1A1MAPTRAB9ALMNA | |
| SCHEMBL789628 | 0.72 | ALPL (0.47) | ALPLALDH1A1MAPTNPSR1LMNA | |
| SCHEMBL12909455 | 0.71 | FEN1 (0.45) | ALDH1A1MAPTMTORHPGDLMNA | |
| SCHEMBL2492632 | 0.71 | GCK (0.49) | ALDH1A1RAB9AHTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012087938-A1 | QUINAZOLINONE DERIVATIVES AS ANTIVIRAL AGENTS | GLAXOSMITHKLINE LLC (US) | 2012-06-28 | — | — | WO | disclosed |
| WO-2012087938-A1 | QUINAZOLINONE DERIVATIVES AS ANTIVIRAL AGENTS | GLAXOSMITHKLINE LLC (US) | 2012-06-28 | — | — | WO | disclosed |