Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 4/20 | 0.49 |
| ▸ | CCR5 | P51681 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 1/20 | 0.46 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.45 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.45 |
| ▸ | LTA4H | P09960 | 1/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.45 |
| ▸ | PLAU | P00749 | 1/20 | 0.45 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.44 |
| ▸ | USP28 | Q96RU2 | 1/20 | 0.44 |
| ▸ | USP25 | Q9UHP3 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30523230 | 1.00 | GCK (0.49) | GCKCCR5ALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL19461605 | 0.87 | GCK (0.40) | GCKCCR5ALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL1577749 | 0.83 | GCK (0.51) | GCKCCR5ALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL26223542 | 0.82 | GCK (0.50) | GCKCCR5SMN1; SMN2MAOBLRRK2 | |
| SCHEMBL30388779 | 0.82 | NPC1 (0.49) | CCR5ALDH1A1SMN1; SMN2MAOBLRRK2 | |
| SCHEMBL28988132 | 0.82 | NPC1 (0.49) | CCR5ALDH1A1SMN1; SMN2MAOBLRRK2 | |
| SCHEMBL2436153 | 0.81 | GCK (0.49) | GCKHTTSMN1; SMN2MAOBLRRK2 | |
| SCHEMBL22332620 | 0.81 | GCK (0.51) | GCKHTTSMN1; SMN2LRRK2MAPK14 | |
| SCHEMBL31456652 | 0.81 | GCK (0.49) | GCKCCR5ALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL16926498 | 0.81 | GCK (0.55) | GCKCCR5ALDH1A1HTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11753376-B2 | Benzyloxy pyridine derivatives and uses thereof | AUTOTAC INC. (KR) | 2023-09-12 | — | — | US | disclosed |
| US-11753376-B2 | Benzyloxy pyridine derivatives and uses thereof | AUTOTAC INC. (KR) | 2023-09-12 | — | — | US | disclosed |
| CN-111148735-B | Nitrogen-containing heteroaryl compounds and pharmaceutical uses thereof | 日本烟草产业株式会社 | 2023-08-08 | — | — | CN | disclosed |
| EP-3693358-B1 | NITROGEN-CONTAINING HETEROARYL COMPOUND, AND PHARMACEUTICAL USE THEREOF | JAPAN TOBACCO INC (JP) | 2023-02-22 | — | — | EP | disclosed |
| US-10752596-B2 | Nitrogen-containing heteroaryl compound and pharmaceutical use thereof | JAPAN TOBACCO INC. (JP) | 2020-08-25 | — | — | US | disclosed |
| US-10752596-B2 | Nitrogen-containing heteroaryl compound and pharmaceutical use thereof | JAPAN TOBACCO INC. (JP) | 2020-08-25 | — | — | US | disclosed |
| EP-3693358-A1 | NITROGEN-CONTAINING HETEROARYL COMPOUND, AND PHARMACEUTICAL USE THEREOF | Japan Tobacco Inc. (JP) | 2020-08-12 | — | — | EP | disclosed |
| CN-111148735-A | Nitrogen-containing heteroaryl compounds and pharmaceutical uses thereof | 日本烟草产业株式会社 | 2020-05-12 | — | — | CN | disclosed |
| US-20190152926-A1 | NITROGEN-CONTAINING HETEROARYL COMPOUND AND PHARMACEUTICAL USE THEREOF | JAPAN TOBACCO INC. (JP) | 2019-05-23 | — | — | US | disclosed |
| US-20190152926-A1 | NITROGEN-CONTAINING HETEROARYL COMPOUND AND PHARMACEUTICAL USE THEREOF | JAPAN TOBACCO INC. (JP) | 2019-05-23 | — | — | US | disclosed |
| US-20130005744-A1 | INHIBITORS OF CATECHOL O-METHYL TRANSFERASE AND THEIR USE IN THE TREATMENT OF PSYCHOTIC DISORDERS | MERCK SHARP & DOHME LLC | 2013-01-03 | — | — | US | disclosed |
| US-20130005744-A1 | INHIBITORS OF CATECHOL O-METHYL TRANSFERASE AND THEIR USE IN THE TREATMENT OF PSYCHOTIC DISORDERS | MERCK SHARP & DOHME LLC | 2013-01-03 | — | — | US | disclosed |
| US-20130005744-A1 | INHIBITORS OF CATECHOL O-METHYL TRANSFERASE AND THEIR USE IN THE TREATMENT OF PSYCHOTIC DISORDERS | MERCK SHARP & DOHME LLC | 2013-01-03 | — | — | US | disclosed |
| WO-2011109261-A1 | INHIBITORS OF CATECHOL O-METHYL TRANSFERASE AND THEIR USE IN THE TREATMENT OF PSYCHOTIC DISORDERS | MERCK SHARP & DOHME CORP. (US) | 2011-09-09 | — | — | WO | disclosed |
| WO-2011109261-A1 | INHIBITORS OF CATECHOL O-METHYL TRANSFERASE AND THEIR USE IN THE TREATMENT OF PSYCHOTIC DISORDERS | MERCK SHARP & DOHME CORP. (US) | 2011-09-09 | — | — | WO | disclosed |
| US-6831175-B2 | Such as N,N-dimethyl-N-(2-((5-((E)-2-pyridin-4-ylvinyl) pyridin-3-yl)oxy)ethyl)amine | ABBOTT LABORATORIES | 2004-12-14 | — | — | US | disclosed |
| EP-1463505-A2 | 3-(PHENYL-ALKOXY)-5-(PHENYL)-PYRIDINE DERIVATIVES AND RELATED COMPOUNDS AS KINASE INHIBITORS FOR THE TREATMENT OF CANCER | Abbott Laboratories (US) | 2004-10-06 | — | — | EP | disclosed |
| US-20030199511-A1 | Kinase inhibitors | ABBVIE INC. | 2003-10-23 | — | — | US | disclosed |
| US-20030187026-A1 | Kinase inhibitors | ABBOTT LABORATORIES | 2003-10-02 | — | — | US | disclosed |
| WO-2003051366-A2 | 3-(PHENYL-ALKOXY)-5-(PHENYL)-PYRIDINE DERIVATIVES AND RELATED COMPOUNDS AS KINASE INHIBITORS FOR THE TREATMENT OF CANCER | ABBOTT LABORATORIES (US) | 2003-06-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030187026-A1 | Kinase inhibitors | MAP3K20, MAP3K19, MAP3K1 | GCK 605/4885CCR5 4201/4885ALDH1A1 3292/4885 |
| US-20030199511-A1 | Kinase inhibitors | MAP3K20, MAP3K19, MAP3K1 | GCK 605/4885CCR5 4201/4885ALDH1A1 3292/4885 |
| US-11753376-B2 | Benzyloxy pyridine derivatives and uses thereof | SQSTM1, ATG7, BECN1 | GCK 1821/4885CCR5 4509/4885ALDH1A1 3915/4885 |
| US-10752596-B2 | Nitrogen-containing heteroaryl compound and pharmaceutical use thereof | SLC2A9, SLC6A19, SLC5A2 | GCK 98/4885CCR5 2481/4885ALDH1A1 923/4885 |
| US-20130005744-A1 | INHIBITORS OF CATECHOL O-METHYL TRANSFERASE AND THEIR USE IN THE TREATMENT OF PSYCHOTIC DISORDERS | COMT, PNMT, TPMT | GCK 2239/4885CCR5 4481/4885ALDH1A1 186/4885 |
| US-20190152926-A1 | NITROGEN-CONTAINING HETEROARYL COMPOUND AND PHARMACEUTICAL USE THEREOF | SLC2A9, SLC6A19, SLC5A2 | GCK 98/4885CCR5 2481/4885ALDH1A1 923/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.