Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CG | P48736 | 9/20 | 0.39 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.36 |
| ▸ | GPR55 | Q9Y2T6 | 2/20 | 0.36 |
| ▸ | PIK3CB | P42338 | 4/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 5/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.34 |
| ▸ | PI4KA | P42356 | 1/20 | 0.34 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.33 |
| ▸ | KDM1A | O60341 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9952021 | 0.80 | PIK3CG (0.36) | PIK3CGPIK3C3GPR55PIK3CBPIK3CD | |
| SCHEMBL9929002 | 0.76 | PIK3C3 (0.40) | PIK3CGPIK3C3GPR55PIK3CBPIK3CD | |
| SCHEMBL9954073 | 0.73 | PIK3CG (0.36) | PIK3CGPIK3C3GPR55PIK3CBPIK3CD | |
| SCHEMBL9928787 | 0.69 | PIK3C3 (0.38) | PIK3CGPIK3C3GPR55PIK3CBPIK3CD | |
| SCHEMBL9954216 | 0.66 | PIK3CD (0.44) | PIK3CGPIK3C3GPR55PIK3CDPTGS2 | |
| SCHEMBL9929356 | 0.66 | PIK3CD (0.42) | PIK3CGPIK3C3GPR55PIK3CBPIK3CD | |
| Hydrochloric Acid SCHEMBL9928961 | 0.66 | PIK3CD (0.42) | PIK3CGPIK3C3GPR55PIK3CBPIK3CD | |
| SCHEMBL9952024 | 0.66 | PIK3CD (0.37) | PIK3CGPIK3C3GPR55PIK3CBPIK3CD | |
| SCHEMBL9953789 | 0.65 | PTGS2 (0.39) | PIK3CGPIK3C3GPR55PIK3CBPIK3CD | |
| SCHEMBL12417957 | 0.63 | PTGS2 (0.48) | PIK3CGPIK3C3PIK3CBPIK3CDPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2655374-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | Incyte Corporation (US) | 2013-10-30 | — | — | EP | disclosed |
| WO-2012087881-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2012-06-28 | — | — | WO | disclosed |