Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | APLNR | P35414 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | CASP3 | P42574 | 2/20 | 0.39 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.39 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.39 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.38 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.38 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.38 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.38 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9954292 | 1.00 | PTGS2 (0.49) | PTGS2MEN1KMT2AATMKDM4E | |
| SCHEMBL9954289 | 1.00 | PTGS2 (0.49) | PTGS2MEN1KMT2AATMKDM4E | |
| SCHEMBL14247421 | 0.83 | MEN1 (0.45) | MEN1KMT2AKDM4EMAPTHTT | |
| SCHEMBL14247296 | 0.83 | MEN1 (0.45) | MEN1KMT2AKDM4EMAPTHTT | |
| SCHEMBL14247294 | 0.83 | MEN1 (0.45) | MEN1KMT2AKDM4EMAPTHTT | |
| SCHEMBL12788397 | 0.76 | KMT2A (0.51) | PTGS2MEN1KMT2AATMMAPT | |
| SCHEMBL12789450 | 0.76 | KMT2A (0.48) | PTGS2MEN1KMT2AATMKDM4E | |
| SCHEMBL9954332 | 0.75 | PTGS2 (0.45) | PTGS2MEN1KMT2AATMAVPR1A | |
| SCHEMBL9953980 | 0.74 | ATM (0.51) | PTGS2MEN1KMT2AATMKDM4E | |
| SCHEMBL9954662 | 0.74 | PI4KA (0.47) | PTGS2MEN1KMT2AATMKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012087938-A1 | QUINAZOLINONE DERIVATIVES AS ANTIVIRAL AGENTS | GLAXOSMITHKLINE LLC (US) | 2012-06-28 | — | — | WO | disclosed |
| WO-2012087938-A1 | QUINAZOLINONE DERIVATIVES AS ANTIVIRAL AGENTS | GLAXOSMITHKLINE LLC (US) | 2012-06-28 | — | — | WO | disclosed |