Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 13/20 | 1.00 |
| ▸ | MAOB | P27338 | 3/20 | 0.70 |
| ▸ | RAB9A | P51151 | 5/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.61 |
| ▸ | NPC1 | O15118 | 3/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.61 |
| ▸ | USP2 | O75604 | 1/20 | 0.61 |
| ▸ | HPGD | P15428 | 2/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.61 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.60 |
| ▸ | STAT1 | P42224 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9956279 | 0.83 | GRM5 (1.00) | GRM5MAOBRAB9AALDH1A1NPC1 | |
| SCHEMBL10025793 | 0.81 | GRM5 (0.80) | GRM5MAOBRAB9AALDH1A1NPC1 | |
| SCHEMBL9954910 | 0.81 | GRM5 (0.77) | GRM5MAOBRAB9AALDH1A1NPC1 | |
| SCHEMBL9955883 | 0.80 | RAB9A (0.78) | GRM5MAOBRAB9AALDH1A1NPC1 | |
| SCHEMBL9955588 | 0.80 | GRM5 (0.70) | GRM5MAOBRAB9AALDH1A1NPC1 | |
| SCHEMBL9955087 | 0.77 | GRM5 (0.80) | GRM5MAOBRAB9AALDH1A1NPC1 | |
| SCHEMBL9956150 | 0.77 | GRM5 (1.00) | GRM5MAOBRAB9AALDH1A1NPC1 | |
| SCHEMBL10025784 | 0.77 | RAB9A (1.00) | GRM5MAOBRAB9AALDH1A1NPC1 | |
| SCHEMBL10025797 | 0.76 | RAB9A (1.00) | GRM5MAOBRAB9AALDH1A1NPC1 | |
| SCHEMBL9953953 | 0.76 | GRM5 (1.00) | GRM5MAOBRAB9AALDH1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012085166-A1 | METABOTROPIC GLUTAMATE RECEPTOR MODULATORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2012-06-28 | — | — | WO | claimed |
| WO-2012085166-A1 | METABOTROPIC GLUTAMATE RECEPTOR MODULATORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2012-06-28 | — | — | WO | disclosed |