Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 5/20 | 0.39 |
| ▸ | HSP90AB1 | P08238 | 4/20 | 0.39 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.39 |
| ▸ | HSP90B1 | P14625 | 1/20 | 0.38 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.38 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL785054 | 0.86 | MAPT (0.43) | MAPTHSP90AA1HSP90AB1ENPP2HSP90B1 | |
| SCHEMBL786189 | 0.84 | MAPT (0.65) | MAPTENPP2PDGFRB | |
| SCHEMBL14496905 | 0.77 | CYP2C19 (0.40) | MAPT | |
| SCHEMBL2246755 | 0.76 | ESR1 (0.41) | MAPT | |
| SCHEMBL1503713 | 0.76 | HSP90AA1 (0.38) | MAPTHSP90AA1HSP90B1 | |
| SCHEMBL741206 | 0.75 | MAPT (0.51) | MAPT | |
| SCHEMBL16870041 | 0.70 | MAPT (0.33) | MAPT | |
| SCHEMBL15309369 | 0.70 | ABHD6 (0.48) | RIPK1HDAC6HDAC8HSP90AA1PDK2 | |
| SCHEMBL18818957 | 0.69 | TP53 (0.33) | MAPT | |
| SCHEMBL24921008 | 0.69 | HTR6 (0.36) | MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012085167-A1 | METABOTROPIC GLUTAMATE RECEPTOR MODULATORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2012-06-28 | — | — | WO | disclosed |