Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 9/20 | 0.84 |
| ▸ | PDGFRB | P09619 | 10/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.51 |
| ▸ | JAK2 | O60674 | 2/20 | 0.50 |
| ▸ | SRC | P12931 | 2/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.49 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.49 |
| ▸ | CDK2 | P24941 | 1/20 | 0.49 |
| ▸ | CDK9 | P50750 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17635122 | 0.92 | KDR (1.00) | KDRPDGFRBHPGDHSP90AB1CCNT1 | |
| SCHEMBL9955600 | 0.90 | KDR (0.74) | KDRPDGFRBTP53 | |
| SCHEMBL9955257 | 0.88 | PDGFRB (0.71) | KDRPDGFRBHSP90AB1JAK2SRC | |
| SCHEMBL17635116 | 0.88 | PDGFRB (0.71) | KDRPDGFRBSMN1; SMN2TP53 | |
| SCHEMBL9955068 | 0.84 | KDR (0.69) | KDRPDGFRBJAK2 | |
| SCHEMBL17620622 | 0.83 | PDGFRB (1.00) | KDRPDGFRBHPGDTP53 | |
| SCHEMBL3536379 | 0.82 | KDR (0.64) | KDRPDGFRBALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL17635120 | 0.80 | PDGFRB (1.00) | KDRPDGFRB | |
| SCHEMBL17620628 | 0.78 | KDR (1.00) | KDRPDGFRBALDH1A1CDK2 | |
| SCHEMBL9954102 | 0.78 | MAOB (0.61) | KDRPDGFRBTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012085167-A1 | METABOTROPIC GLUTAMATE RECEPTOR MODULATORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2012-06-28 | — | — | WO | disclosed |