Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 7/20 | 0.69 |
| ▸ | PDGFRB | P09619 | 9/20 | 0.52 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | GRM5 | P41594 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | FYN | P06241 | 1/20 | 0.47 |
| ▸ | JAK2 | O60674 | 1/20 | 0.46 |
| ▸ | JAK3 | P52333 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9955998 | 0.88 | MAOB (0.57) | KDRPDGFRBSIRT5MAPK1GRM5 | |
| SCHEMBL9955600 | 0.88 | KDR (0.74) | KDRPDGFRBGRM5MAPTFYN | |
| SCHEMBL17635116 | 0.84 | PDGFRB (0.71) | KDRPDGFRBSIRT5MAPK1GRM5 | |
| SCHEMBL9955095 | 0.84 | KDR (0.84) | KDRPDGFRBJAK2 | |
| SCHEMBL17635122 | 0.82 | KDR (1.00) | KDRPDGFRB | |
| SCHEMBL9954960 | 0.78 | MAOB (0.54) | KDRPDGFRBSIRT5MAPK1GRM5 | |
| SCHEMBL9955097 | 0.77 | KDR (0.49) | KDRPDGFRBSIRT5GRM5MAPT | |
| SCHEMBL9955606 | 0.76 | PDGFRB (0.55) | KDRPDGFRBSIRT5MAPK1GRM5 | |
| SCHEMBL9953930 | 0.76 | KDR (0.50) | KDRPDGFRBSIRT5GRM5MAPT | |
| SCHEMBL9954102 | 0.76 | MAOB (0.61) | KDRPDGFRBSIRT5GRM5MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012085167-A1 | METABOTROPIC GLUTAMATE RECEPTOR MODULATORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2012-06-28 | — | — | WO | disclosed |