Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 8/20 | 0.74 |
| ▸ | PDGFRB | P09619 | 10/20 | 0.58 |
| ▸ | GRM5 | P41594 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | FYN | P06241 | 1/20 | 0.47 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9955095 | 0.90 | KDR (0.84) | KDRPDGFRBTP53 | |
| SCHEMBL17635116 | 0.90 | PDGFRB (0.71) | KDRPDGFRBGRM5TP53FYN | |
| SCHEMBL9955068 | 0.88 | KDR (0.69) | KDRPDGFRBGRM5MAPTFYN | |
| SCHEMBL9954102 | 0.87 | MAOB (0.61) | KDRPDGFRBGRM5TP53MAPT | |
| SCHEMBL17635122 | 0.85 | KDR (1.00) | KDRPDGFRB | |
| SCHEMBL9955805 | 0.85 | PDGFRB (0.56) | KDRPDGFRBGRM5MAPTFYN | |
| SCHEMBL12498045 | 0.78 | MAPK1 (0.58) | KDRPDGFRBMAPT | |
| SCHEMBL9955257 | 0.78 | PDGFRB (0.71) | KDRPDGFRBGRM5 | |
| SCHEMBL9955875 | 0.76 | MAOB (0.61) | KDRPDGFRBGRM5MAPT | |
| SCHEMBL9954695 | 0.76 | PDGFRB (0.66) | KDRPDGFRBGRM5MAPTFYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012085167-A1 | METABOTROPIC GLUTAMATE RECEPTOR MODULATORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2012-06-28 | — | — | WO | disclosed |