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SCHEMBL9955567

SCHEMBL9955567

Cc1ccc(-c2cn3nc(-c4ccc(C=CC(=O)O)cc4)ccc3n2)cc1NC(=O)C(C)(C)C

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ CSNK1D P48730 9/20 0.41
▸ CSNK1E P49674 9/20 0.41
▸ RIPK1 Q13546 2/20 0.38
▸ THRB P10828 1/20 0.37
▸ MAPT P10636 2/20 0.36
▸ TP53 P04637 2/20 0.36
▸ RXFP1 Q9HBX9 2/20 0.36
▸ LMNA P02545 1/20 0.36
▸ KDM4E B2RXH2 2/20 0.35
▸ ALDH1A1 P00352 2/20 0.35
▸ HPGD P15428 2/20 0.35
▸ SMN1; SMN2 Q16637 2/20 0.35
▸ NPC1 O15118 1/20 0.35
▸ CASP3 P42574 1/20 0.35
▸ RAB9A P51151 1/20 0.35
▸ SENP8 Q96LD8 1/20 0.35
▸ SENP7 Q9BQF6 1/20 0.35
▸ SENP6 Q9GZR1 1/20 0.35
▸ HDAC1 Q13547 1/20 0.35
▸ ADORA1 P30542 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9957083 0.94 HDAC1 (0.43) CSNK1DCSNK1ERIPK1THRBMAPT
SCHEMBL10277364 0.92 CSNK1D (0.39) CSNK1DCSNK1ERIPK1MAPTLMNA
SCHEMBL9956317 0.90 CYP3A4 (0.38) CSNK1DCSNK1ERIPK1MAPTTP53
SCHEMBL9955801 0.87 HDAC1 (0.44) CSNK1DCSNK1EHDAC1
SCHEMBL9957565 0.87 CSNK1D (0.44) CSNK1DCSNK1ERIPK1MAPTTP53
SCHEMBL9957221 0.86 CSNK1D (0.44) CSNK1DCSNK1ERIPK1MAPTTP53
SCHEMBL9957147 0.86 CSNK1D (0.44) CSNK1DCSNK1ERIPK1MAPTTP53
SCHEMBL9956960 0.85 CSNK1D (0.42) CSNK1DCSNK1ERIPK1MAPTKDM4E
SCHEMBL9956538 0.85 MAPT (0.46) CSNK1DCSNK1ERIPK1MAPTTP53
SCHEMBL9956165 0.84 THRB (0.39) CSNK1DCSNK1ETHRBMAPTTP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2635578-A1 2-ARYLIMIDAZO[1,2-B]PYRIDAZINE, 2-PHENYLIMIDAZO[1,2-A]PYRIDINE, AND 2-PHENYLIMIDAZO[1,2-A]PYRAZINE DERIVATIVES Hengrui (USA) Ltd. (US) 2013-09-11 — — EP claimed
US-20120178751-A1 2-ARYLIMIDAZO[1,2-B]PYRIDAZINE, 2-PHENYLIMIDAZO[1,2-A]PYRIDINE, AND 2-PHENYLIMIDAZO[1,2-A]PYRAZINE DERIVATIVES HENGRUI (USA), LTD. 2012-07-12 — — US claimed
WO-2012088411-A1 2-ARYLIMIDAZO[1,2-B]PYRIDAZINE, 2-PHENYLIMIDAZO[1,2-A]PYRIDINE, AND 2-PHENYLIMIDAZO[1,2-A]PYRAZINE DERIVATIVES PAMLICO PHARMACEUTICAL INC. (US) 2012-06-28 — — WO claimed
EP-2635578-B1 2-ARYLIMIDAZO[1,2-B]PYRIDAZINE, 2-PHENYLIMIDAZO[1,2-A]PYRIDINE, AND 2-PHENYLIMIDAZO[1,2-A]PYRAZINE DERIVATIVES HENGRUI USA LTD (US) 2015-12-16 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120178751-A1 2-ARYLIMIDAZO[1,2-B]PYRIDAZINE, 2-PHENYLIMIDAZO[1,2-A]PYRIDINE, AND 2-PHENYLIMIDAZO[1,2-A]PYRAZINE DERIVATIVES PRXL2A, CDK2, CCNA2 CSNK1D 655/4885CSNK1E 852/4885RIPK1 4566/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.