SCHEMBL9956262

SCHEMBL9956262

CC(C)(CCc1ccccc1)O[Si](C)(C)C

nearest known ligand 0.40

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
KCNH2 Q12809 1/20 0.39
ALDH1A1 P00352 1/20 0.37
HPGD P15428 1/20 0.37
ALOX15 P16050 1/20 0.37
ALOX12 P18054 1/20 0.37
CASP1 P29466 1/20 0.37
HSD17B10 Q99714 1/20 0.37
TAAR1 Q96RJ0 4/20 0.36
ATM Q13315 1/20 0.36
SLC6A2 P23975 1/20 0.36
TDP1 Q9NUW8 2/20 0.35
CYP2A6 P11509 1/20 0.35
HTR2A P28223 1/20 0.35
SMN1; SMN2 Q16637 1/20 0.35
LOXL2 Q9Y4K0 1/20 0.35
IDO1 P14902 1/20 0.34
AOC3 Q16853 1/20 0.34
LMNA P02545 1/20 0.34
CYP2D6 P10635 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6431354 0.79 ALDH1A1 (0.42) ALDH1A1HPGDALOX15ALOX12CASP1
SCHEMBL19509051 0.78 ALDH1A1 (0.41) ALDH1A1HPGDALOX15ALOX12CASP1
SCHEMBL6724280 0.78 DRD2 (0.38) TAAR1ATMCYP2D6
SCHEMBL964291 0.76 ALDH1A1 (0.39) ALDH1A1HPGDALOX15ALOX12CASP1
SCHEMBL9446218 0.74 TAAR1 (0.42) ALDH1A1HPGDALOX15ALOX12CASP1
SCHEMBL21555860 0.73 ALDH1A1 (0.50) ALDH1A1HPGDALOX15ALOX12CASP1
SCHEMBL315316 0.72 ALDH1A1 (0.48) ALDH1A1HPGDALOX15ALOX12CASP1
SCHEMBL4980093 0.72 ALDH1A1 (0.37) ALDH1A1HPGDALOX15ALOX12CASP1
SCHEMBL29143219 0.72 ALDH1A1 (0.35) ALDH1A1HPGDALOX15ALOX12CASP1
SCHEMBL873380 0.70 ALDH1A1 (0.48) ALDH1A1TDP1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2655349-A1 METHODS OF MAKING DIASTEREOMERIC ORGANIC COMPOUNDS Boehringer Ingelheim International GmbH (DE) 2013-10-30 EP disclosed
WO-2012087720-A1 METHODS OF MAKING DIASTEREOMERIC ORGANIC COMPOUNDS BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2012-06-28 WO disclosed