Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 14/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 14/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 13/20 | 0.49 |
| ▸ | HDAC4 | P56524 | 13/20 | 0.49 |
| ▸ | HDAC7 | Q8WUI4 | 13/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 13/20 | 0.49 |
| ▸ | HDAC10 | Q969S8 | 13/20 | 0.49 |
| ▸ | HDAC11 | Q96DB2 | 13/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 13/20 | 0.49 |
| ▸ | HDAC9 | Q9UKV0 | 13/20 | 0.49 |
| ▸ | HDAC5 | Q9UQL6 | 13/20 | 0.49 |
| ▸ | BRD4 | O60885 | 1/20 | 0.45 |
| ▸ | ESR1 | P03372 | 1/20 | 0.45 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.45 |
| ▸ | PDE4A | P27815 | 1/20 | 0.45 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.45 |
| ▸ | HTR6 | P50406 | 1/20 | 0.45 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.45 |
| ▸ | ASPH | Q12797 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 5/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9956344 | 1.00 | HDAC1 (0.49) | HDAC1HDAC8HDAC3HDAC4HDAC7 | |
| SCHEMBL9957589 | 0.89 | HDAC1 (0.49) | HDAC1HDAC8HDAC3HDAC4HDAC7 | |
| SCHEMBL9957586 | 0.89 | HDAC1 (0.49) | HDAC1HDAC8HDAC3HDAC4HDAC7 | |
| SCHEMBL9956467 | 0.84 | ALDH1A1 (0.46) | HDAC1HDAC8HDAC3HDAC4HDAC7 | |
| SCHEMBL9956469 | 0.84 | ALDH1A1 (0.46) | HDAC1HDAC8HDAC3HDAC4HDAC7 | |
| SCHEMBL9956640 | 0.82 | HDAC1 (0.45) | HDAC1HDAC8HDAC3HDAC4HDAC7 | |
| SCHEMBL9956350 | 0.82 | HDAC1 (0.43) | HDAC1HDAC8HDAC3HDAC4HDAC7 | |
| SCHEMBL9956346 | 0.82 | HDAC1 (0.43) | HDAC1HDAC8HDAC3HDAC4HDAC7 | |
| SCHEMBL9956251 | 0.81 | MAPT (0.43) | HDAC1HDAC8HDAC3HDAC4HDAC7 | |
| SCHEMBL9956253 | 0.81 | MAPT (0.43) | HDAC1HDAC8HDAC3HDAC4HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2635578-A1 | 2-ARYLIMIDAZO[1,2-B]PYRIDAZINE, 2-PHENYLIMIDAZO[1,2-A]PYRIDINE, AND 2-PHENYLIMIDAZO[1,2-A]PYRAZINE DERIVATIVES | Hengrui (USA) Ltd. (US) | 2013-09-11 | — | — | EP | claimed |
| US-20120178751-A1 | 2-ARYLIMIDAZO[1,2-B]PYRIDAZINE, 2-PHENYLIMIDAZO[1,2-A]PYRIDINE, AND 2-PHENYLIMIDAZO[1,2-A]PYRAZINE DERIVATIVES | HENGRUI (USA), LTD. | 2012-07-12 | — | — | US | claimed |
| WO-2012088411-A1 | 2-ARYLIMIDAZO[1,2-B]PYRIDAZINE, 2-PHENYLIMIDAZO[1,2-A]PYRIDINE, AND 2-PHENYLIMIDAZO[1,2-A]PYRAZINE DERIVATIVES | PAMLICO PHARMACEUTICAL INC. (US) | 2012-06-28 | — | — | WO | claimed |
| EP-2635578-B1 | 2-ARYLIMIDAZO[1,2-B]PYRIDAZINE, 2-PHENYLIMIDAZO[1,2-A]PYRIDINE, AND 2-PHENYLIMIDAZO[1,2-A]PYRAZINE DERIVATIVES | HENGRUI USA LTD (US) | 2015-12-16 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120178751-A1 | 2-ARYLIMIDAZO[1,2-B]PYRIDAZINE, 2-PHENYLIMIDAZO[1,2-A]PYRIDINE, AND 2-PHENYLIMIDAZO[1,2-A]PYRAZINE DERIVATIVES | PRXL2A, CDK2, CCNA2 | HDAC1 315/4885HDAC8 1832/4885HDAC3 421/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.