Sugi Predict

Sugi Predict / Compounds / SCHEMBL9956470

SCHEMBL9956470

SCHEMBL9956470

Cc1ccc(-c2cn3nc(Cl)ccc3n2)cc1NC(=O)c1cccc(/C=C/C(=O)NO)c1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ HDAC4 P56524 3/20 0.45
▸ MEF2D Q14814 1/20 0.45
▸ HDAC1 Q13547 7/20 0.44
▸ HDAC3 O15379 3/20 0.44
▸ KDM4E B2RXH2 2/20 0.41
▸ ALDH1A1 P00352 2/20 0.41
▸ GLA P06280 2/20 0.41
▸ GAA P10253 2/20 0.41
▸ LMNA P02545 1/20 0.41
▸ POLB P06746 2/20 0.41
▸ HDAC8 Q9BY41 5/20 0.40
▸ HDAC6 Q9UBN7 5/20 0.40
▸ HDAC7 Q8WUI4 2/20 0.40
▸ HDAC2 Q92769 2/20 0.40
▸ HDAC9 Q9UKV0 2/20 0.40
▸ HDAC5 Q9UQL6 2/20 0.40
▸ ABL1 P00519 1/20 0.40
▸ PDGFRB P09619 1/20 0.40
▸ BCR P11274 1/20 0.40
▸ KDR P35968 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9956476 1.00 HDAC4 (0.45) HDAC4MEF2DHDAC1HDAC3KDM4E
SCHEMBL9956301 0.89 POLB (0.42) KDM4EALDH1A1GLAGAALMNA
SCHEMBL9956305 0.89 POLB (0.42) KDM4EALDH1A1GLAGAALMNA
SCHEMBL9956469 0.89 ALDH1A1 (0.46) HDAC4MEF2DHDAC1HDAC3KDM4E
SCHEMBL9956467 0.89 ALDH1A1 (0.46) HDAC4MEF2DHDAC1HDAC3KDM4E
SCHEMBL10277189 0.85 HDAC4 (0.42) HDAC4MEF2DHDAC1HDAC3KDM4E
SCHEMBL9955610 0.85 HDAC4 (0.42) HDAC4MEF2DHDAC1HDAC3KDM4E
SCHEMBL9957589 0.84 HDAC1 (0.49) HDAC4HDAC1HDAC3HDAC8HDAC6
SCHEMBL9957586 0.84 HDAC1 (0.49) HDAC4HDAC1HDAC3HDAC8HDAC6
SCHEMBL9956529 0.82 ALDH1A1 (0.41) HDAC4MEF2DHDAC1HDAC3KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2635578-A1 2-ARYLIMIDAZO[1,2-B]PYRIDAZINE, 2-PHENYLIMIDAZO[1,2-A]PYRIDINE, AND 2-PHENYLIMIDAZO[1,2-A]PYRAZINE DERIVATIVES Hengrui (USA) Ltd. (US) 2013-09-11 — — EP claimed
US-20120178751-A1 2-ARYLIMIDAZO[1,2-B]PYRIDAZINE, 2-PHENYLIMIDAZO[1,2-A]PYRIDINE, AND 2-PHENYLIMIDAZO[1,2-A]PYRAZINE DERIVATIVES HENGRUI (USA), LTD. 2012-07-12 — — US claimed
WO-2012088411-A1 2-ARYLIMIDAZO[1,2-B]PYRIDAZINE, 2-PHENYLIMIDAZO[1,2-A]PYRIDINE, AND 2-PHENYLIMIDAZO[1,2-A]PYRAZINE DERIVATIVES PAMLICO PHARMACEUTICAL INC. (US) 2012-06-28 — — WO claimed
EP-2635578-B1 2-ARYLIMIDAZO[1,2-B]PYRIDAZINE, 2-PHENYLIMIDAZO[1,2-A]PYRIDINE, AND 2-PHENYLIMIDAZO[1,2-A]PYRAZINE DERIVATIVES HENGRUI USA LTD (US) 2015-12-16 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120178751-A1 2-ARYLIMIDAZO[1,2-B]PYRIDAZINE, 2-PHENYLIMIDAZO[1,2-A]PYRIDINE, AND 2-PHENYLIMIDAZO[1,2-A]PYRAZINE DERIVATIVES PRXL2A, CDK2, CCNA2 HDAC4 1823/4885MEF2D 2681/4885HDAC1 315/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.