Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.31 |
| ▸ | MAOA | P21397 | 1/20 | 0.30 |
| ▸ | MAOB | P27338 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8754149 | 0.79 | HDAC8 (0.37) | POLBTDP1ALDH1A1CYP2C9HDAC8 | |
| SCHEMBL13244620 | 0.78 | PARP1 (0.36) | CYP2C9HDAC8MAOAMAOB | |
| SCHEMBL9957816 | 0.75 | ACACB (0.41) | — | |
| SCHEMBL863464 | 0.74 | MAPT (0.35) | — | |
| SCHEMBL3020098 | 0.73 | HDAC8 (0.34) | POLBTDP1ALDH1A1HDAC8 | |
| SCHEMBL9902946 | 0.73 | RXRA (0.49) | POLBALDH1A1 | |
| SCHEMBL11957475 | 0.72 | HDAC8 (0.34) | CYP2C9HDAC8MAOAMAOB | |
| SCHEMBL15565140 | 0.69 | IDO1 (0.36) | POLBTDP1ALDH1A1CYP2C9HDAC8 | |
| SCHEMBL948451 | 0.69 | PTGS1 (0.42) | ALDH1A1CYP2C9HDAC8MAOB | |
| SCHEMBL12344408 | 0.69 | ACACB (0.41) | HDAC8MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2655345-A1 | ARYL TRIAZOLE COMPOUNDS WITH ANTITUMOURAL ACTIVITY | SIGMA-TAU Research Switzerland S.A. (CH) | 2013-10-30 | — | — | EP | disclosed |
| WO-2012084602-A1 | ARYL TRIAZOLE COMPOUNDS WITH ANTITUMOURAL ACTIVITY | SIGMA-TAU RESEARCH SWITZERLAND S.A. (CH) | 2012-06-28 | — | — | WO | disclosed |