Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.34 |
| ▸ | GABRP | O00591 | 1/20 | 0.31 |
| ▸ | GABRD | O14764 | 1/20 | 0.31 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.31 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.31 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.31 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.31 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.31 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.31 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.31 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.31 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.31 |
| ▸ | GABRE | P78334 | 1/20 | 0.31 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.31 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.31 |
| ▸ | GABRG3 | Q99928 | 1/20 | 0.31 |
| ▸ | GABRQ | Q9UN88 | 1/20 | 0.31 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 2/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15062696 | 0.91 | HDAC8 (0.31) | HDAC8 | |
| SCHEMBL20487117 | 0.83 | DUT (0.34) | HDAC8DUT | |
| SCHEMBL8812553 | 0.83 | CYP2A6 (0.46) | ALDH1A1 | |
| SCHEMBL8754149 | 0.82 | HDAC8 (0.37) | HDAC8KEAP1POLBTDP1ALDH1A1 | |
| SCHEMBL15062712 | 0.81 | CYP1A1 (0.35) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL15320670 | 0.80 | HRH3 (0.30) | — | |
| SCHEMBL3008315 | 0.80 | GABRA1 (0.30) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL6885043 | 0.79 | BACE1 (0.33) | BACE1 | |
| SCHEMBL12855670 | 0.78 | AGXT (0.52) | — | |
| SCHEMBL906834 | 0.78 | IDO1 (0.48) | BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250136580-A1 | INDOLINONE DERIVATIVES AS INHIBITORS OF MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM | 2025-05-01 | — | — | US | disclosed |
| US-20210317107-A1 | INDOLINONE DERIVATIVES AS INHIBITORS OF MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM | 2021-10-14 | — | — | US | disclosed |
| US-10981896-B2 | Indolinone derivatives as inhibitors of maternal embryonic leucine zipper kinase | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2021-04-20 | — | — | US | disclosed |
| EP-3114126-B1 | 1,2-DIHYDRO-3H-PYRROLO[1,2-C]IMIDAZOL-3-ONE DERIVATIVES AND THEIR USE AS ANTIBACTERIAL AGENTS | IDORSIA PHARMACEUTICALS LTD (CH) | 2018-10-31 | — | — | EP | disclosed |
| US-10106544-B2 | 1,2-dihydro-3H-pyrrolo[1,2-C]imidazol-3-one derivatives and their use as antibacterial agents | IDORSIA PHARMACEUTICALS LTD (CH) | 2018-10-23 | — | — | US | disclosed |
| WO-2018160967-A1 | INDOLINONE DERIVATIVES AS INHIBITORS OF MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2018-09-07 | — | — | WO | disclosed |
| US-9896479-B2 | Functionalized naphthalene fluorophores | Kay M. Brummond (US) | 2018-02-20 | — | — | US | disclosed |
| US-20170107223-A1 | 1,2-DIHYDRO-3H-PYRROLO[1,2-C]IMIDAZOL-3-ONE DERIVATIVES AND THEIR USE AS ANTIBACTERIAL AGENTS | IDORSIA PHARMACEUTICALS LTD (CH) | 2017-04-20 | — | — | US | disclosed |
| US-9617256-B2 | Antibacterial agents | ACHAOGEN, INC. (US) | 2017-04-11 | — | — | US | disclosed |
| US-20170088549-A1 | ANTIBACTERIAL AGENTS | ACHAOGEN, INC. | 2017-03-30 | — | — | US | disclosed |
| US-8809012-B2 | Labeling agent and methods for simultaneous sequencing and quantification of multiple peptides and proteins using the same | Postach Academy-Industry Foundation (KR) | 2014-08-19 | — | — | US | disclosed |
| US-20130315841-A1 | FUNCTIONALIZED NAPHTHALENE FLUOROPHORES | BRUMMOND, KAY M | 2013-11-28 | — | — | US | disclosed |
| EP-2662353-A2 | Antibacterial agents | Achaogen, Inc. (US) | 2013-11-13 | — | — | EP | disclosed |
| WO-2013150534-A1 | NOVEL TARGETING AGENTS FOR DIAGNOSTIC AND THERAPEUTIC INDICATIONS | APOSENSE LTD. (IL) | 2013-10-10 | — | — | WO | disclosed |
| US-20130183704-A1 | Labeling Agent and Methods for Simultaneous Sequencing and Quantification of Multiple Peptides and Proteins Using the Same | POSTECH ACADEMY-INDUSTRY FOUNDATION (KR) | 2013-07-18 | — | — | US | disclosed |
| EP-2610243-A2 | LABELING AGENT AND AMINO ACID SEQUENCE USING SAME, AND METHOD FOR PERFORMING SIMULTANEOUS QUANTITATIVE ANALYSIS OF MULTIPLE PROTEINS | Postech Academy-industry Foundation (KR) | 2013-07-03 | — | — | EP | disclosed |
| US-20100190766-A1 | ANTIBACTERIAL AGENTS | ACHAOGEN, INC. (US) | 2010-07-29 | — | — | US | disclosed |
| US-20100190766-A1 | ANTIBACTERIAL AGENTS | ACHAOGEN, INC. (US) | 2010-07-29 | — | — | US | disclosed |
| EP-2170814-A2 | ANTIBACTERIAL AGENTS | Achaogen, Inc. (US) | 2010-04-07 | — | — | EP | disclosed |
| WO-2008154642-A2 | ANTIBACTERIAL AGENTS | ACHAOGEN, INC. (US) | 2008-12-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170088549-A1 | ANTIBACTERIAL AGENTS | MRPL21, SI, ABCB11 | HDAC8 1902/4885GABRP 1635/4885GABRD 1482/4885 |
| US-20100190766-A1 | ANTIBACTERIAL AGENTS | MRPL21, SI, ABCB11 | HDAC8 1902/4885GABRP 1635/4885GABRD 1482/4885 |
| US-10106544-B2 | 1,2-dihydro-3H-pyrrolo[1,2-C]imidazol-3-one derivatives and their use as antibacterial agents | CCNI, H1-0, H1-3 | HDAC8 2237/4885GABRP 3413/4885GABRD 3915/4885 |
| US-20130183704-A1 | Labeling Agent and Methods for Simultaneous Sequencing and Quantification of Multiple Peptides and Proteins Using the Same | YWHAQ, IAPP, RPS27A | HDAC8 3273/4885GABRP 1893/4885GABRD 3589/4885 |
| US-20210317107-A1 | INDOLINONE DERIVATIVES AS INHIBITORS OF MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE | MELK, HIPK1, HIPK3 | HDAC8 1338/4885GABRP 2684/4885GABRD 3197/4885 |
| US-10981896-B2 | Indolinone derivatives as inhibitors of maternal embryonic leucine zipper kinase | MELK, HIPK1, HIPK3 | HDAC8 1596/4885GABRP 2230/4885GABRD 2876/4885 |
| US-20170107223-A1 | 1,2-DIHYDRO-3H-PYRROLO[1,2-C]IMIDAZOL-3-ONE DERIVATIVES AND THEIR USE AS ANTIBACTERIAL AGENTS | CCNI, H1-0, H1-3 | HDAC8 2237/4885GABRP 3413/4885GABRD 3915/4885 |
| US-20130315841-A1 | FUNCTIONALIZED NAPHTHALENE FLUOROPHORES | NCL, SNW1, NEK1 | HDAC8 4803/4885GABRP 4608/4885GABRD 4660/4885 |
| US-20250136580-A1 | INDOLINONE DERIVATIVES AS INHIBITORS OF MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE | MELK, HIPK1, HIPK3 | HDAC8 1338/4885GABRP 2684/4885GABRD 3197/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.