Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 8/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 5/20 | 0.48 |
| ▸ | HDAC4 | P56524 | 5/20 | 0.48 |
| ▸ | HDAC7 | Q8WUI4 | 5/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.48 |
| ▸ | HDAC10 | Q969S8 | 5/20 | 0.48 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.48 |
| ▸ | HDAC9 | Q9UKV0 | 5/20 | 0.48 |
| ▸ | HDAC5 | Q9UQL6 | 5/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | XBP1 | P17861 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MITF | O75030 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9958790 | 0.78 | CA1 (0.42) | HDAC1HDAC3HDAC4HDAC7HDAC2 | |
| SCHEMBL27753624 | 0.71 | CYP19A1 (0.47) | NPSR1MAPTALDH1A1HTTKMT2A | |
| SCHEMBL17273861 | 0.71 | KMT2A (0.46) | HDAC1HDAC3HDAC4HDAC7HDAC2 | |
| SCHEMBL16701588 | 0.71 | HDAC1 (0.47) | HDAC1HDAC3HDAC4HDAC7HDAC2 | |
| SCHEMBL9977895 | 0.70 | PDE10A (0.43) | HDAC1HDAC3HDAC4HDAC7HDAC2 | |
| SCHEMBL8817130 | 0.70 | KMT2A (0.62) | NPSR1MAPTXBP1ALDH1A1HTT | |
| SCHEMBL25381118 | 0.70 | CA1 (0.58) | HDAC1HDAC3HDAC4HDAC7HDAC2 | |
| SCHEMBL3240039 | 0.70 | GAA (0.67) | MAPTALDH1A1KMT2AKDM4EMITF | |
| SCHEMBL13624115 | 0.70 | ALDH1A1 (0.50) | NPSR1MAPTALDH1A1HTTKMT2A | |
| SCHEMBL15338801 | 0.69 | KMT2A (0.60) | NPSR1MAPTALDH1A1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1984340-B1 | ANTHRANILAMIDE/2-AMINO-HETEROARENE CARBOXAMIDE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2012-06-27 | — | — | EP | disclosed |
| CN-101379036-B | Anthranilamide/2-amino-heteroarene carboxamide derivatives | HOFFMANN LA ROCHE | 2011-06-01 | — | — | CN | disclosed |
| CN-101379036-A | Anthranilamide/2-amino-heteroarene carboxamide derivatives | HOFFMANN LA ROCHE (CH) | 2009-03-04 | — | — | CN | disclosed |