Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | HTT | P42858 | 3/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.50 |
| ▸ | ACSS2 | Q9NR19 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.41 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.41 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.40 |
| ▸ | KIF11 | P52732 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 5/20 | 0.39 |
| ▸ | NPC1 | O15118 | 4/20 | 0.39 |
| ▸ | RAB9A | P51151 | 4/20 | 0.39 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14405047 | 0.85 | ACSS2 (0.43) | ALDH1A1HTTNPSR1ACSS2KIF11 | |
| SCHEMBL27753624 | 0.84 | CYP19A1 (0.47) | ALDH1A1HTTNPSR1HPGDSMN1; SMN2 | |
| SCHEMBL20782019 | 0.80 | ACSS2 (0.40) | ALDH1A1HTTNPSR1ACSS2HPGD | |
| SCHEMBL31306191 | 0.79 | KEAP1 (0.61) | ALDH1A1ACSS2HPGDSMN1; SMN2KDM4E | |
| SCHEMBL3447669 | 0.79 | KMT2A (0.48) | ALDH1A1NPSR1ACSS2HPGDSMN1; SMN2 | |
| SCHEMBL26112584 | 0.79 | SCN4A (0.51) | ALDH1A1NPSR1ACSS2HPGDSMN1; SMN2 | |
| SCHEMBL8005007 | 0.79 | MAPT (0.41) | ALDH1A1ACSS2HPGDSMN1; SMN2KDM4E | |
| SCHEMBL21051373 | 0.79 | ACSS2 (0.43) | ALDH1A1NPSR1ACSS2HPGDSMN1; SMN2 | |
| SCHEMBL13634221 | 0.79 | ALDH1A1 (0.49) | ALDH1A1HTTNPSR1ACSS2HPGD | |
| SCHEMBL12245363 | 0.78 | KEAP1 (0.60) | ALDH1A1HTTNPSR1HPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090291945-A1 | CYSTEINE PROTEASE INHIBITORS | TEIJIN PHARMA LIMITED (JP) | 2009-11-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090291945-A1 | CYSTEINE PROTEASE INHIBITORS | CTSE, SPINT2, CTSF | ALDH1A1 2506/4885HTT 1913/4885NPSR1 2711/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.