Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | MET | P08581 | 4/20 | 0.41 |
| ▸ | KIT | P10721 | 1/20 | 0.41 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | RIOK2 | Q9BVS4 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13861102 | 0.89 | MEN1 (0.45) | MEN1KMT2ASMN1; SMN2CYP1A2CYP2C9 | |
| SCHEMBL4335435 | 0.87 | MEN1 (0.45) | MEN1KMT2ASMN1; SMN2CYP1A2CYP2C9 | |
| SCHEMBL13861093 | 0.87 | MEN1 (0.45) | MEN1KMT2ASMN1; SMN2CYP1A2CYP2C9 | |
| SCHEMBL13861099 | 0.86 | MEN1 (0.44) | MEN1KMT2ASMN1; SMN2CYP1A2CYP2C9 | |
| SCHEMBL4343929 | 0.85 | MEN1 (0.48) | MEN1KMT2ASMN1; SMN2CYP1A2CYP2C9 | |
| SCHEMBL4324360 | 0.84 | MEN1 (0.49) | MEN1KMT2ASMN1; SMN2CYP1A2CYP2C9 | |
| SCHEMBL4339451 | 0.83 | ALDH1A1 (0.46) | MEN1KMT2ASMN1; SMN2CYP1A2CYP2C9 | |
| SCHEMBL4335519 | 0.83 | MEN1 (0.47) | MEN1KMT2AMETKITPDGFRA | |
| SCHEMBL4335063 | 0.83 | MET (0.45) | MEN1KMT2ASMN1; SMN2CYP1A2CYP2C9 | |
| SCHEMBL4335093 | 0.82 | MEN1 (0.48) | MEN1KMT2ASMN1; SMN2CYP1A2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1719762-B1 | NOVEL PYRIDINE DERIVATIVE AND PYRIMIDINE DERIVATIVE (1) | EISAI R&D MAN CO LTD (JP) | 2012-06-27 | — | — | EP | claimed |