Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2B | P41595 | 5/20 | 0.46 |
| ▸ | HRH1 | P35367 | 3/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.46 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.46 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.46 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.46 |
| ▸ | DRD2 | P14416 | 1/20 | 0.46 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.46 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.46 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.46 |
| ▸ | DRD1 | P21728 | 1/20 | 0.46 |
| ▸ | DRD4 | P21917 | 1/20 | 0.46 |
| ▸ | DRD5 | P21918 | 1/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL995811 | 1.00 | HTR2B (0.46) | HTR2BHRH1KCNH2ALDH1A1CHRM2 | |
| SCHEMBL7206976 | 1.00 | HTR2B (0.46) | HTR2BHRH1KCNH2ALDH1A1CHRM2 | |
| SCHEMBL7206969 | 0.87 | HTR2B (0.46) | HTR2BHRH1KCNH2ALDH1A1CHRM2 | |
| SCHEMBL7206966 | 0.87 | HTR2B (0.46) | HTR2BHRH1KCNH2ALDH1A1CHRM2 | |
| SCHEMBL654984 | 0.86 | CCR1 (0.42) | HRH1ALDH1A1CHRM2LMNACCR1 | |
| SCHEMBL654983 | 0.86 | CCR1 (0.42) | HRH1ALDH1A1CHRM2LMNACCR1 | |
| SCHEMBL7210953 | 0.86 | CCR1 (0.42) | HRH1ALDH1A1CHRM2LMNACCR1 | |
| SCHEMBL14288484 | 0.85 | HTR2B (0.47) | HTR2BHRH1KCNH2ALDH1A1CHRM2 | |
| SCHEMBL7210855 | 0.83 | ALDH1A1 (0.42) | HTR2BHRH1KCNH2ALDH1A1CHRM2 | |
| SCHEMBL7210858 | 0.83 | ALDH1A1 (0.42) | HTR2BHRH1KCNH2ALDH1A1CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9334283-B2 | CCR1 antagonists and methods of use thereof | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2016-05-10 | — | — | US | disclosed |
| US-20150005338-A1 | CCR1 ANTAGONISTS AND METHODS OF USE THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2015-01-01 | — | — | US | disclosed |
| US-20130289063-A1 | CCR1 ANTAGONISTS AND METHODS OF USE THEREFOR | MILLENNIUM PHARM INC (US) | 2013-10-31 | — | — | US | disclosed |
| US-20110021777-A1 | PROCESS IMPROVEMENT | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2011-01-27 | — | — | US | disclosed |
| US-20110021777-A1 | PROCESS IMPROVEMENT | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2011-01-27 | — | — | US | disclosed |
| US-20110021777-A1 | PROCESS IMPROVEMENT | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2011-01-27 | — | — | US | disclosed |
| WO-2009070556-A1 | PROCESS IMPROVEMENT | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2009-06-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110021777-A1 | PROCESS IMPROVEMENT | PARP3, BRD3, CYP4F3 | HTR2B 1757/4885HRH1 1005/4885KCNH2 1873/4885 |
| US-20130289063-A1 | CCR1 ANTAGONISTS AND METHODS OF USE THEREFOR | CCR1, CCRL2, CCR4 | HTR2B 541/4885HRH1 59/4885KCNH2 3390/4885 |
| US-20150005338-A1 | CCR1 ANTAGONISTS AND METHODS OF USE THEREOF | CCR1, CCR3, CCR4 | HTR2B 478/4885HRH1 63/4885KCNH2 2997/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.