Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK1 | Q13464 | 2/20 | 0.47 |
| ▸ | CA1 | P00915 | 2/20 | 0.45 |
| ▸ | CA2 | P00918 | 2/20 | 0.45 |
| ▸ | SCN8A | Q9UQD0 | 2/20 | 0.43 |
| ▸ | CCNC | P24863 | 1/20 | 0.41 |
| ▸ | CDK8 | P49336 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | PHGDH | O43175 | 1/20 | 0.37 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.37 |
| ▸ | MITF | O75030 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3576790 | 0.82 | CA1 (0.47) | CA1CA2SCN8AKMT2AKDM4E | |
| SCHEMBL5176818 | 0.79 | CA1 (0.62) | CA1CA2SCN8AKMT2AGAA | |
| SCHEMBL13778175 | 0.79 | ALDH1A1 (0.56) | CA1CA2KMT2AKDM4EMITF | |
| SCHEMBL3235999 | 0.77 | KDM4E (0.58) | ROCK1CA1CA2SCN8AKMT2A | |
| SCHEMBL5175994 | 0.76 | CA1 (0.47) | CA1CA2SCN8AKMT2A | |
| SCHEMBL3580858 | 0.74 | CA1 (0.48) | ROCK1CA1CA2SCN8AKMT2A | |
| SCHEMBL3244176 | 0.74 | CA1 (0.50) | ROCK1CA1CA2KMT2AKDM4E | |
| SCHEMBL47299 | 0.74 | CA1 (0.50) | ROCK1CA1CA2SCN8AKMT2A | |
| SCHEMBL20902780 | 0.74 | CA1 (0.71) | CA1CA2KMT2AGAA | |
| SCHEMBL24258324 | 0.74 | SIRT2 (0.43) | SCN8AADRB2GAAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1984340-B1 | ANTHRANILAMIDE/2-AMINO-HETEROARENE CARBOXAMIDE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2012-06-27 | — | — | EP | disclosed |