Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 2/20 | 0.47 |
| ▸ | CA2 | P00918 | 2/20 | 0.47 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.42 |
| ▸ | DAO | P14920 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MITF | O75030 | 1/20 | 0.38 |
| ▸ | KDM1A | O60341 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | CCR3 | P51677 | 2/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.37 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.37 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9958370 | 0.82 | ROCK1 (0.47) | CA1CA2SCN8AKMT2AGAA | |
| SCHEMBL5176818 | 0.81 | CA1 (0.62) | CA1CA2SCN8AKMT2AGAA | |
| SCHEMBL13778175 | 0.78 | ALDH1A1 (0.56) | CA1CA2KMT2AGAAKDM4E | |
| SCHEMBL22493337 | 0.77 | DAO (0.45) | DAOKMT2AGAAKDM4EKDM1A | |
| SCHEMBL3580858 | 0.76 | CA1 (0.48) | CA1CA2SCN8AKMT2AGAA | |
| SCHEMBL14303885 | 0.76 | HRH3 (0.47) | DAOKMT2AGAAKDM1AMAOA | |
| SCHEMBL1397552 | 0.76 | ROCK1 (0.52) | SCN8AKMT2AKDM4EMEN1LMNA | |
| SCHEMBL20902780 | 0.76 | CA1 (0.71) | CA1CA2KMT2AGAAHDAC3 | |
| SCHEMBL3576786 | 0.75 | P2RX7 (0.50) | EPHX2NR1H4LMNA | |
| SCHEMBL27828893 | 0.74 | MRGPRX4 (0.50) | DAOKMT2AKDM4EHDAC1HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7678818-B2 | Anthranilamide and 2-amino-heteroarene-carboxamide compounds | HOFFMANN-LA ROCHE INC. (US) | 2010-03-16 | — | — | US | claimed |
| EP-1984340-B1 | ANTHRANILAMIDE/2-AMINO-HETEROARENE CARBOXAMIDE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2012-06-27 | — | — | EP | disclosed |