Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 9/20 | 0.48 |
| ▸ | KDR | P35968 | 12/20 | 0.48 |
| ▸ | BRAF | P15056 | 7/20 | 0.48 |
| ▸ | PDGFRB | P09619 | 5/20 | 0.47 |
| ▸ | FLT3 | P36888 | 5/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.47 |
| ▸ | ABL1 | P00519 | 2/20 | 0.47 |
| ▸ | BCR | P11274 | 2/20 | 0.47 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.47 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.47 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.47 |
| ▸ | LCK | P06239 | 1/20 | 0.47 |
| ▸ | LYN | P07948 | 1/20 | 0.47 |
| ▸ | RET | P07949 | 1/20 | 0.47 |
| ▸ | HCK | P08631 | 1/20 | 0.47 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.47 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.47 |
| ▸ | ABL2 | P42684 | 1/20 | 0.47 |
| ▸ | FRK | P42685 | 1/20 | 0.47 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9958100 | 0.94 | MET (0.47) | METKDRBRAFPDGFRBFLT3 | |
| SCHEMBL9958072 | 0.92 | MET (0.58) | METKDRBRAFPDGFRBFLT3 | |
| SCHEMBL13861591 | 0.90 | MET (0.58) | METKDRBRAFPDGFRBFLT3 | |
| SCHEMBL9958797 | 0.87 | MET (0.51) | METKDRBRAFPDGFRBFLT3 | |
| SCHEMBL9958536 | 0.86 | MET (0.49) | METKDRBRAFPDGFRBFLT3 | |
| SCHEMBL4330221 | 0.84 | MET (0.66) | METKDRBRAFPDGFRBFLT3 | |
| SCHEMBL13861551 | 0.83 | MET (0.56) | METKDRBRAFPDGFRBFLT3 | |
| SCHEMBL4333105 | 0.83 | MET (0.69) | METKDRBRAFPDGFRBFLT3 | |
| SCHEMBL13861601 | 0.82 | MET (0.60) | METKDRBRAFPDGFRBFLT3 | |
| SCHEMBL13861599 | 0.82 | MET (0.49) | METKDRBRAFPDGFRBFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1719762-B1 | NOVEL PYRIDINE DERIVATIVE AND PYRIMIDINE DERIVATIVE (1) | EISAI R&D MAN CO LTD (JP) | 2012-06-27 | — | — | EP | claimed |