Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 4/20 | 0.49 |
| ▸ | BCHE | P06276 | 2/20 | 0.49 |
| ▸ | MET | P08581 | 1/20 | 0.45 |
| ▸ | USP30 | Q70CQ3 | 3/20 | 0.41 |
| ▸ | MMP1 | P03956 | 2/20 | 0.39 |
| ▸ | MMP9 | P14780 | 2/20 | 0.39 |
| ▸ | MMP13 | P45452 | 2/20 | 0.39 |
| ▸ | BTK | Q06187 | 2/20 | 0.39 |
| ▸ | SFRP1 | Q8N474 | 4/20 | 0.39 |
| ▸ | MMP3 | P08254 | 1/20 | 0.39 |
| ▸ | MMP7 | P09237 | 1/20 | 0.39 |
| ▸ | WNT3 | P56703 | 2/20 | 0.38 |
| ▸ | HPGDS | O60760 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.37 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2277377 | 1.00 | HTR6 (0.49) | HTR6BCHEMETUSP30MMP1 | |
| SCHEMBL2278046 | 1.00 | HTR6 (0.49) | HTR6BCHEMETUSP30MMP1 | |
| SCHEMBL2280321 | 0.98 | HTR6 (0.47) | HTR6BCHEMETUSP30MMP1 | |
| SCHEMBL30480383 | 0.95 | HTR6 (0.47) | HTR6BCHEMETUSP30MMP1 | |
| SCHEMBL2283395 | 0.95 | HTR6 (0.47) | HTR6BCHEMETUSP30MMP1 | |
| SCHEMBL2276066 | 0.93 | MET (0.46) | HTR6BCHEMETUSP30MMP1 | |
| SCHEMBL2275115 | 0.92 | HTR6 (0.49) | HTR6BCHEMETUSP30SFRP1 | |
| SCHEMBL29711926 | 0.89 | MET (0.44) | HTR6BCHEMETMMP1MMP9 | |
| SCHEMBL30480458 | 0.88 | MET (0.42) | HTR6BCHEMETUSP30SFRP1 | |
| SCHEMBL2279609 | 0.88 | HTR6 (0.52) | HTR6BCHEUSP30BTKSFRP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012085176-A1 | TRICYCLIC PYRAZINONE COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF AS JANUS KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2012-06-28 | — | — | WO | disclosed |
| WO-2012085176-A1 | TRICYCLIC PYRAZINONE COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF AS JANUS KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2012-06-28 | — | — | WO | disclosed |