Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F11 | P03951 | 3/20 | 0.41 |
| ▸ | F2 | P00734 | 2/20 | 0.41 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.41 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.41 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.41 |
| ▸ | LIPG | Q9Y5X9 | 5/20 | 0.40 |
| ▸ | LPL | P06858 | 4/20 | 0.40 |
| ▸ | P4HB | P07237 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 8/20 | 0.39 |
| ▸ | CA2 | P00918 | 8/20 | 0.39 |
| ▸ | CA9 | Q16790 | 8/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA3 | P07451 | 1/20 | 0.38 |
| ▸ | CA4 | P22748 | 1/20 | 0.38 |
| ▸ | CA6 | P23280 | 1/20 | 0.38 |
| ▸ | CA5A | P35218 | 1/20 | 0.38 |
| ▸ | CA7 | P43166 | 1/20 | 0.38 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.38 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9958895 | 1.00 | F11 (0.41) | F11F2PRSS1PRSS2PRSS3 | |
| SCHEMBL2033871 | 0.88 | LIPG (0.41) | F11F2PRSS1PRSS2PRSS3 | |
| SCHEMBL2033870 | 0.88 | LIPG (0.41) | F11F2PRSS1PRSS2PRSS3 | |
| SCHEMBL2034656 | 0.85 | LIPG (0.45) | F11F2PRSS1PRSS2PRSS3 | |
| SCHEMBL15900053 | 0.84 | F11 (0.42) | F11F2PRSS1PRSS2PRSS3 | |
| SCHEMBL10226740 | 0.83 | AAK1 (0.45) | F11F2PRSS1PRSS2PRSS3 | |
| SCHEMBL10274517 | 0.83 | AAK1 (0.45) | F11F2PRSS1PRSS2PRSS3 | |
| SCHEMBL17872784 | 0.83 | LIPG (0.43) | F11F2PRSS1PRSS2PRSS3 | |
| SCHEMBL2700792 | 0.83 | LIPG (0.43) | F11F2PRSS1PRSS2PRSS3 | |
| SCHEMBL362044 | 0.83 | LIPG (0.43) | F11F2PRSS1PRSS2PRSS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2303269-B1 | INHIBITORS OF AKT ACTIVITY | MERCK SHARP & DOHME (US) | 2014-07-30 | — | — | EP | disclosed |
| US-8207169-B2 | Substituted [1,2,4]triazolo[4′,3′:1,6]pyrido[2,3-b]pyrazines of the formula D | MSD K.K. (JP) | 2012-06-26 | — | — | US | disclosed |