Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.48 |
| ▸ | KMO | O15229 | 1/20 | 0.46 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | CFD | P00746 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10237675 | 0.84 | L3MBTL1 (0.48) | NPC1RAB9ASMN1; SMN2TSHRL3MBTL1 | |
| SCHEMBL31429406 | 0.81 | RECQL (0.51) | NPC1RAB9ASMN1; SMN2TSHRL3MBTL1 | |
| SCHEMBL25741023 | 0.80 | CHRM2 (0.49) | NPC1RAB9ASMN1; SMN2TSHRL3MBTL1 | |
| SCHEMBL3904701 | 0.77 | DRD2 (0.52) | NPC1RAB9ASMN1; SMN2TSHRL3MBTL1 | |
| SCHEMBL25740903 | 0.76 | CHRM2 (0.48) | NPC1RAB9ASMN1; SMN2TSHRL3MBTL1 | |
| SCHEMBL25740899 | 0.76 | CHRM2 (0.48) | NPC1RAB9ASMN1; SMN2TSHRL3MBTL1 | |
| SCHEMBL9960182 | 0.76 | CHRM2 (0.46) | NPC1RAB9ASMN1; SMN2TSHRL3MBTL1 | |
| SCHEMBL15284866 | 0.76 | NPC1 (0.47) | NPC1RAB9ASMN1; SMN2TSHRL3MBTL1 | |
| SCHEMBL15284867 | 0.76 | NPC1 (0.47) | NPC1RAB9ASMN1; SMN2TSHRL3MBTL1 | |
| SCHEMBL5946285 | 0.75 | RECQL (0.54) | NPC1RAB9ASMN1; SMN2TSHRL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2654748-A1 | INDAZOLE DERIVATIVES USEFUL AS ERK INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2013-10-30 | — | — | EP | disclosed |
| WO-2012087772-A1 | INDAZOLE DERIVATIVES USEFUL AS ERK INHIBITORS | SCHERING CORPORATION (US) | 2012-06-28 | — | — | WO | disclosed |