Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.36 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.36 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.36 |
| ▸ | PTGIR | P43119 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 3/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CHKA | P35790 | 1/20 | 0.34 |
| ▸ | COMT | P21964 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9959927 | 1.00 | SIGMAR1 (0.39) | SIGMAR1SMN1; SMN2POLBPKMTSHR | |
| SCHEMBL9960736 | 0.76 | SIGMAR1 (0.49) | SIGMAR1SMN1; SMN2POLBPKMABCB1 | |
| SCHEMBL25341634 | 0.66 | SIGMAR1 (0.51) | SIGMAR1SMN1; SMN2POLBPKMABCB1 | |
| SCHEMBL7879156 | 0.65 | IDO1 (0.44) | — | |
| SCHEMBL979576 | 0.64 | SIGMAR1 (0.69) | SIGMAR1SMN1; SMN2POLBPKMPTGIR | |
| SCHEMBL6785733 | 0.64 | IDO1 (0.44) | SMN1; SMN2TSHRALDH1A1MEN1KMT2A | |
| SCHEMBL19077903 | 0.64 | ALDH1A1 (0.46) | SIGMAR1SMN1; SMN2POLBALDH1A1MEN1 | |
| SCHEMBL1043952 | 0.63 | SIGMAR1 (0.85) | SIGMAR1SMN1; SMN2POLBPKMPTGIR | |
| SCHEMBL20804352 | 0.63 | SIGMAR1 (0.85) | SIGMAR1SMN1; SMN2POLBPKMPTGIR | |
| SCHEMBL19285228 | 0.63 | SIGMAR1 (0.85) | SIGMAR1SMN1; SMN2POLBPKMPTGIR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012088402-A1 | SYNTHESIS OF CONOLIDINE AND DISCOVERY OF A POTENT NON-OPIOID ANALGESIC FOR PAIN | THE SCRIPPS RESEARCH INSTITUTE (US) | 2012-06-28 | — | — | WO | claimed |