Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.54 |
| ▸ | NR3C1 | P04150 | 12/20 | 0.47 |
| ▸ | BTK | Q06187 | 1/20 | 0.45 |
| ▸ | PGR | P06401 | 2/20 | 0.45 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.44 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.44 |
| ▸ | SMO | Q99835 | 2/20 | 0.43 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.43 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.43 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.42 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25228277 | 0.78 | SMO (0.48) | SMOMAPK8MAPK10CYP11B1CYP11B2 | |
| SCHEMBL16292062 | 0.78 | OPRK1 (0.56) | — | |
| SCHEMBL16292066 | 0.78 | OPRK1 (0.56) | — | |
| SCHEMBL5381387 | 0.78 | RAB9A (0.59) | NR3C1PGRSMOMAPK8MAPK10 | |
| SCHEMBL19781171 | 0.76 | PIM3 (0.54) | PIM3SMO | |
| SCHEMBL9959878 | 0.73 | MAPK1 (0.52) | — | |
| SCHEMBL15875013 | 0.73 | HPGD (0.47) | NR3C1PIM3SMOMAPK8MAPK10 | |
| SCHEMBL2102012 | 0.72 | PARP10 (1.00) | PARP10 | |
| SCHEMBL1667310 | 0.72 | PLA2G10 (0.55) | NR3C1PGRSMOCYP11B1CYP11B2 | |
| SCHEMBL19781154 | 0.72 | LRRK2 (0.52) | PIM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2654748-A1 | INDAZOLE DERIVATIVES USEFUL AS ERK INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2013-10-30 | — | — | EP | disclosed |
| WO-2012087772-A1 | INDAZOLE DERIVATIVES USEFUL AS ERK INHIBITORS | SCHERING CORPORATION (US) | 2012-06-28 | — | — | WO | disclosed |