Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 2/20 | 0.39 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.39 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
| ▸ | TYK2 | P29597 | 1/20 | 0.36 |
| ▸ | JAK3 | P52333 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | MAP3K5 | Q99683 | 3/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 4/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9959475 | 0.81 | JAK2 (0.41) | JAK2CD274JAK1TYK2JAK3 | |
| SCHEMBL21986438 | 0.77 | JAK2 (0.45) | JAK2CD274JAK1TYK2JAK3 | |
| SCHEMBL9929348 | 0.75 | JAK2 (0.45) | JAK2CD274JAK1TYK2JAK3 | |
| SCHEMBL9928675 | 0.72 | JAK2 (0.43) | JAK2CD274JAK1TYK2JAK3 | |
| SCHEMBL9929087 | 0.69 | JAK2 (0.39) | JAK2CD274JAK1TYK2JAK3 | |
| SCHEMBL9928883 | 0.68 | JAK2 (0.42) | JAK2CD274JAK1TYK2JAK3 | |
| SCHEMBL2015194 | 0.67 | KDM4E (0.40) | TSHRMAPTKDM4EALDH1A1NPSR1 | |
| SCHEMBL9929511 | 0.67 | JAK2 (0.50) | JAK2CD274JAK1TYK2JAK3 | |
| SCHEMBL38651468 | 0.67 | JAK2 (0.43) | JAK2CD274JAK1TYK2JAK3 | |
| SCHEMBL22128054 | 0.65 | JAK2 (0.48) | JAK2CD274JAK1TYK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2655374-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | Incyte Corporation (US) | 2013-10-30 | — | — | EP | disclosed |
| WO-2012087881-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2012-06-28 | — | — | WO | disclosed |