Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 8/20 | 0.38 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.36 |
| ▸ | AXL | P30530 | 1/20 | 0.36 |
| ▸ | MERTK | Q12866 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | FFAR1 | O14842 | 4/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.34 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9953069 | 0.94 | LMNA (0.42) | LMNACLK4PIK3CDAXLMERTK | |
| SCHEMBL9954211 | 0.86 | LMNA (0.39) | LMNACLK4ALDH1A1CYP1A2CYP3A4 | |
| Trifluoroacetic Acid SCHEMBL9928929 | 0.84 | PIK3CD (0.49) | LMNACLK4PIK3CDAXLMERTK | |
| SCHEMBL9960866 | 0.81 | LMNA (0.36) | LMNACLK4ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL9952164 | 0.81 | PIK3CD (0.41) | PIK3CDAXLMERTK | |
| SCHEMBL9953781 | 0.81 | PIK3CD (0.39) | PIK3CDAXLMERTK | |
| SCHEMBL9960500 | 0.79 | PIK3CD (0.40) | PIK3CDAXLMERTKALDH1A1 | |
| SCHEMBL9952881 | 0.78 | PIK3CD (0.42) | LMNACLK4PIK3CDAXLMERTK | |
| SCHEMBL9952230 | 0.77 | PIK3CD (0.56) | CLK4PIK3CDAXLMERTK | |
| SCHEMBL9929069 | 0.77 | PIK3CD (0.55) | LMNACLK4PIK3CDAXLMERTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2655374-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | Incyte Corporation (US) | 2013-10-30 | — | — | EP | disclosed |
| WO-2012087881-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2012-06-28 | — | — | WO | disclosed |