Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 12/20 | 0.41 |
| ▸ | AXL | P30530 | 2/20 | 0.41 |
| ▸ | MERTK | Q12866 | 2/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.36 |
| ▸ | RPS6KB1 | P23443 | 4/20 | 0.36 |
| ▸ | AURKA | O14965 | 3/20 | 0.36 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.35 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.34 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9951999 | 0.92 | RPS6KB1 (0.33) | PIK3CDAXLMERTKRPS6KB1AURKA | |
| SCHEMBL9953781 | 0.86 | PIK3CD (0.39) | PIK3CDAXLMERTKMAP4K4PIK3CG | |
| SCHEMBL9960500 | 0.85 | PIK3CD (0.40) | PIK3CDAXLMERTKMAP4K4PIK3CG | |
| SCHEMBL9952230 | 0.84 | PIK3CD (0.56) | PIK3CDAXLMERTKMAP4K4AURKA | |
| SCHEMBL9952881 | 0.83 | PIK3CD (0.42) | PIK3CDAXLMERTKMAP4K4AURKA | |
| SCHEMBL2051140 | 0.82 | PIK3CD (0.45) | PIK3CDAXLMERTKMAP4K4RPS6KB1 | |
| SCHEMBL9953069 | 0.82 | LMNA (0.42) | PIK3CDAXLMERTKMAP4K4 | |
| SCHEMBL9929317 | 0.81 | PIK3CD (0.56) | PIK3CDAXLMERTKMAP4K4PIK3CG | |
| Trifluoroacetic Acid SCHEMBL9960862 | 0.81 | LMNA (0.38) | PIK3CDAXLMERTK | |
| SCHEMBL9953061 | 0.80 | PIK3CD (0.39) | PIK3CDAXLMERTKPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2655374-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | Incyte Corporation (US) | 2013-10-30 | — | — | EP | claimed |
| WO-2012087881-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2012-06-28 | — | — | WO | claimed |
| EP-2655374-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | Incyte Corporation (US) | 2013-10-30 | — | — | EP | disclosed |
| WO-2012087881-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2012-06-28 | — | — | WO | disclosed |