Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.49 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.49 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.48 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.48 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.47 |
| ▸ | CTSL | P07711 | 1/20 | 0.47 |
| ▸ | CTSK | P43235 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | CA4 | P22748 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
| ▸ | BCHE | P06276 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL677997 | 0.85 | FOLH1 (0.59) | FOLH1CTSLCTSK | |
| SCHEMBL2921260 | 0.85 | FOLH1 (0.59) | FOLH1CTSLCTSK | |
| SCHEMBL7624700 | 0.85 | FOLH1 (0.59) | FOLH1CTSLCTSK | |
| SCHEMBL29400872 | 0.85 | ITGB3 (0.58) | ITGB3ITGA2BMEN1KMT2ANPSR1 | |
| SCHEMBL27273354 | 0.84 | SIRT2 (0.54) | SIRT2SIRT1ITGB3ITGA2BCTSL | |
| SCHEMBL6802740 | 0.84 | MEN1 (0.55) | FOLH1CTSLMEN1KMT2ANPSR1 | |
| SCHEMBL17444427 | 0.81 | ITGB3 (0.58) | SIRT2SIRT1ITGB3ITGA2BMEN1 | |
| SCHEMBL17444429 | 0.81 | ITGB3 (0.58) | SIRT2SIRT1ITGB3ITGA2BMEN1 | |
| SCHEMBL3624630 | 0.81 | FOLH1 (0.55) | SIRT2SIRT1FOLH1CTSLCTSK | |
| SCHEMBL21232384 | 0.81 | FOLH1 (0.52) | SIRT2SIRT1FOLH1CTSLCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2655398-A2 | EFFICIENT PEPTIDE COUPLINGS AND THEIR USE IN THE SYNTHESIS AND ISOLATION OF A CYCLOPENTA (G) QUINAZOLINE TRISODIUM SALT | Onyx Pharmaceuticals, Inc. (US) | 2013-10-30 | — | — | EP | disclosed |
| WO-2012087888-A2 | EFFICIENT PEPTIDE COUPLINGS AND THEIR USE IN THE SYNTHESIS AND ISOLATION OF A CYCLOPENTA (G) QUINAZOLINE TRISODIUM SALT | ONYX PHARMACEUTICALS, INC. (US) | 2012-06-28 | — | — | WO | disclosed |