Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP1 | P29466 | 4/20 | 0.56 |
| ▸ | CASP3 | P42574 | 4/20 | 0.56 |
| ▸ | CASP9 | P55211 | 4/20 | 0.56 |
| ▸ | CASP7 | P55210 | 2/20 | 0.56 |
| ▸ | BCHE | P06276 | 2/20 | 0.52 |
| ▸ | ACHE | P22303 | 2/20 | 0.52 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.52 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.52 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.52 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.52 |
| ▸ | ECE1 | P42892 | 3/20 | 0.51 |
| ▸ | MME | P08473 | 2/20 | 0.51 |
| ▸ | CASP4 | P49662 | 2/20 | 0.50 |
| ▸ | CASP8 | Q14790 | 2/20 | 0.50 |
| ▸ | CASP10 | Q92851 | 2/20 | 0.50 |
| ▸ | CASP5 | P51878 | 1/20 | 0.50 |
| ▸ | CASP6 | P55212 | 1/20 | 0.50 |
| ▸ | CTSK | P43235 | 3/20 | 0.49 |
| ▸ | CTSB | P07858 | 2/20 | 0.49 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9962261 | 0.89 | CASP3 (0.53) | CASP1CASP3CASP9CASP7BCHE | |
| SCHEMBL20740990 | 0.87 | CASP3 (0.54) | CASP1CASP3CASP9CASP7ECE1 | |
| SCHEMBL7888291 | 0.87 | CASP3 (0.54) | CASP1CASP3CASP9CASP7ECE1 | |
| SCHEMBL19015971 | 0.87 | CASP3 (0.54) | CASP1CASP3CASP9CASP7ECE1 | |
| SCHEMBL7889716 | 0.86 | CASP3 (0.65) | CASP1CASP3CASP9CASP7ECE1 | |
| SCHEMBL7262083 | 0.85 | BCHE (0.59) | BCHEACHECACNA1FCACNA1DCACNA1S | |
| SCHEMBL9962279 | 0.84 | CASP3 (0.79) | CASP1CASP3CASP9CASP7CASP4 | |
| SCHEMBL9962287 | 0.84 | CASP3 (0.66) | CASP1CASP3CASP9CASP7CASP4 | |
| SCHEMBL9961981 | 0.83 | CASP3 (0.64) | CASP1CASP3CASP9CASP7ECE1 | |
| SCHEMBL7888146 | 0.83 | CASP3 (0.55) | CASP1CASP3CASP9CASP7BCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9045524-B2 | Selective caspase inhibitors and uses thereof | NOVAGENESIS FOUNDATION (CH) | 2015-06-02 | — | — | US | disclosed |
| US-20120157394-A1 | SELECTIVE CASPASE INHIBITORS AND USES THEREOF | NEW WORLD LABORATORIES, INC. (CA) | 2012-06-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120157394-A1 | SELECTIVE CASPASE INHIBITORS AND USES THEREOF | CASP1, VIP, CASP5 | CASP1 1/4885CASP3 6/4885CASP9 10/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.