Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CD274 | Q9NZQ7 | 8/20 | 0.46 |
| ▸ | FFAR1 | O14842 | 4/20 | 0.41 |
| ▸ | PDK2 | Q15119 | 5/20 | 0.36 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.34 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9964472 | 0.90 | CD274 (0.49) | CD274FFAR1PDK2MTNR1AMTNR1B | |
| SCHEMBL9964480 | 0.86 | CD274 (0.46) | CD274FFAR1PDK2MTNR1AMTNR1B | |
| SCHEMBL9964466 | 0.84 | FFAR1 (0.35) | CD274FFAR1 | |
| SCHEMBL9964471 | 0.84 | CD274 (0.48) | CD274FFAR1PDK2MTNR1AMTNR1B | |
| SCHEMBL9964469 | 0.82 | CD274 (0.47) | CD274FFAR1PDK2MTNR1AMTNR1B | |
| SCHEMBL9964488 | 0.79 | MAPK14 (0.35) | FFAR1 | |
| SCHEMBL9964477 | 0.78 | CD274 (0.44) | CD274PDK2MTNR1AMTNR1BMEN1 | |
| SCHEMBL9964368 | 0.78 | CD274 (0.45) | CD274FFAR1PDK2MTNR1AMTNR1B | |
| SCHEMBL9964460 | 0.76 | FFAR1 (0.42) | CD274FFAR1 | |
| SCHEMBL9964454 | 0.74 | FFAR1 (0.39) | CD274FFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8476287-B2 | 3-hydroxy-5-arylisothiazole derivative | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 2013-07-02 | — | — | US | disclosed |
| US-8476287-B2 | 3-hydroxy-5-arylisothiazole derivative | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 2013-07-02 | — | — | US | disclosed |
| US-20120157459-A1 | NOVEL 3-HYDROXY-5-ARYLISOTHIAZOLE DERIVATIVE | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 2012-06-21 | — | — | US | disclosed |
| US-20120157459-A1 | NOVEL 3-HYDROXY-5-ARYLISOTHIAZOLE DERIVATIVE | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 2012-06-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120157459-A1 | NOVEL 3-HYDROXY-5-ARYLISOTHIAZOLE DERIVATIVE | GPR119, GPR27, NR0B1 | CD274 4376/4885FFAR1 39/4885PDK2 3025/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.