Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 6/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 6/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.45 |
| ▸ | MAOA | P21397 | 2/20 | 0.42 |
| ▸ | MAOB | P27338 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | F10 | P00742 | 9/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
| ▸ | CALML3 | P27482 | 1/20 | 0.35 |
| ▸ | SDHA | P31040 | 1/20 | 0.35 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.35 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.34 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9964911 | 0.85 | KCNH2 (0.44) | KCNH2MAOAMAOBCYP2C19F10 | |
| SCHEMBL4555076 | 0.85 | MAOA (0.47) | KCNH2MAOAMAOBCYP2C19F10 | |
| SCHEMBL9929840 | 0.85 | MAOA (0.46) | KCNH2MAOAMAOBCYP2C19F10 | |
| SCHEMBL9930084 | 0.84 | KCNH2 (0.43) | KCNH2HDAC1HDAC2HDAC3MAOA | |
| SCHEMBL9964912 | 0.83 | KCNH2 (0.42) | KCNH2MAOAMAOBCYP2C19F10 | |
| SCHEMBL9930383 | 0.83 | KCNH2 (0.42) | KCNH2MAOAMAOBCYP2C19F10 | |
| SCHEMBL9090265 | 0.82 | KCNH2 (0.53) | KCNH2MAOAMAOBCYP2C19F10 | |
| SCHEMBL9092477 | 0.82 | KCNH2 (0.53) | KCNH2MAOAMAOBCYP2C19F10 | |
| SCHEMBL9090234 | 0.81 | KCNH2 (0.49) | KCNH2MAOAMAOBCYP2C19F10 | |
| SCHEMBL9093206 | 0.81 | KCNH2 (0.49) | KCNH2MAOAMAOBCYP2C19F10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120157434-A1 | Antimicrobial heterocyclic compounds for treatment of bacterial infections | CSO of MicuRx Pharmaceuticals, Inc. | 2012-06-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120157434-A1 | Antimicrobial heterocyclic compounds for treatment of bacterial infections | NISCH, NOD1, NQO1 | KCNH2 1295/4885HDAC1 167/4885HDAC2 659/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.