Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 6/20 | 0.42 |
| ▸ | NOS3 | P29474 | 1/20 | 0.41 |
| ▸ | NOS2 | P35228 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | TEAD1 | P28347 | 1/20 | 0.39 |
| ▸ | MAP3K12 | Q12852 | 3/20 | 0.38 |
| ▸ | IDH2 | P48735 | 1/20 | 0.38 |
| ▸ | BRAF | P15056 | 1/20 | 0.37 |
| ▸ | AURKA | O14965 | 2/20 | 0.35 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.35 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9938726 | 0.90 | SYK (0.40) | SYKNOS3NOS2ALDH1A1GAA | |
| SCHEMBL9972399 | 0.83 | IDH2 (0.41) | SYKNOS3NOS2ALDH1A1GAA | |
| SCHEMBL25894573 | 0.74 | SYK (0.38) | SYKALDH1A1GAAL3MBTL1TEAD1 | |
| SCHEMBL17443159 | 0.73 | IDH2 (0.45) | SYKNOS3NOS2ALDH1A1GAA | |
| SCHEMBL20124507 | 0.73 | SYK (0.37) | SYKALDH1A1GAAL3MBTL1TEAD1 | |
| SCHEMBL9965317 | 0.71 | NOS3 (0.42) | SYKNOS3NOS2ALDH1A1L3MBTL1 | |
| SCHEMBL9943626 | 0.71 | ALDH1A1 (0.42) | SYKALDH1A1GAAL3MBTL1TEAD1 | |
| SCHEMBL22135110 | 0.69 | IDH2 (0.38) | SYKALDH1A1GAAL3MBTL1TEAD1 | |
| SCHEMBL9939354 | 0.69 | MAPK10 (0.44) | SYKALDH1A1GAAL3MBTL1MAP3K12 | |
| SCHEMBL9943489 | 0.67 | CLK1 (0.40) | SYKALDH1A1GAAL3MBTL1IDH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012080953-A1 | COMPOUNDS USEFUL FOR TREATING AIDS | SPLICOS (FR) | 2012-06-21 | — | — | WO | disclosed |