SCHEMBL996549

SCHEMBL996549

O=CCc1cccnc1Cl

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 2/20 0.41
LMNA P02545 1/20 0.41
CASP3 P42574 1/20 0.40
SENP8 Q96LD8 1/20 0.40
SENP7 Q9BQF6 1/20 0.40
SENP6 Q9GZR1 1/20 0.40
KDM1A O60341 1/20 0.39
MAOB P27338 1/20 0.39
TRIM24 O15164 1/20 0.38
TRIM33 Q9UPN9 1/20 0.38
FAAH O00519 1/20 0.36
P2RX7 Q99572 1/20 0.35
SCN2A Q99250 1/20 0.35
SCN10A Q9Y5Y9 1/20 0.35
ALDH1A1 P00352 1/20 0.35
DPP4 P27487 1/20 0.35
NFE2L2 Q16236 3/20 0.35
POLB P06746 1/20 0.35
KDM4E B2RXH2 1/20 0.34
CYP1A2 P05177 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27449298 0.80 TSHR (0.33) SMN1; SMN2CASP3SENP8SENP7SENP6
SCHEMBL2064639 0.80 ALDH1A1 (0.42) SMN1; SMN2LMNACASP3SENP8SENP7
SCHEMBL11744380 0.79 ALDH1A1 (0.38) TRIM24TRIM33ALDH1A1KDM4ECYP1A2
SCHEMBL7410762 0.77 DPP4 (0.40) SMN1; SMN2LMNACASP3SENP8SENP7
SCHEMBL23852687 0.77
SCHEMBL805420 0.77
SCHEMBL1157182 0.76 TRIM24 (0.52) TRIM24TRIM33ALDH1A1KDM4ECYP1A2
SCHEMBL12481228 0.76 KDM4E (0.38) SMN1; SMN2LMNATRIM24TRIM33ALDH1A1
SCHEMBL1645573 0.76 P2RX7 (0.41) TRIM24TRIM33P2RX7KDM4ECYP1A2
SCHEMBL21054513 0.76 BACE1 (0.42) SMN1; SMN2KDM1AMAOBTRIM24TRIM33

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3180339-A1 6-ALKYNYL-PYRIDINE DERIVATIVES AS SMAC MIMETICS Boehringer Ingelheim International GmbH (DE) 2017-06-21 EP disclosed
EP-3126362-A1 ANTI-FIBROTIC PYRIDINONES Intermune, Inc. (US) 2017-02-08 EP disclosed
WO-2016023858-A1 6-ALKYNYL-PYRIDINE DERIVATIVES AS SMAC MIMETICS BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2016-02-18 WO disclosed
WO-2015187934-A1 FUNCTIONALIZED HETROARYL ENONES EXHIBITING NRF2 ACTIVATION AND THEIR METHOD OF USE CUREVEDA, LLC (US) 2015-12-10 WO disclosed
WO-2015153683-A1 ANTI-FIBROTIC PYRIDINONES INTERMUNE, INC. (US) 2015-10-08 WO disclosed
EP-2903991-A1 ANTI-FIBROTIC PYRIDINONES Intermune, Inc. (US) 2015-08-12 EP disclosed
WO-2014055548-A1 ANTI-FIBROTIC PYRIDINONES INTERMUNE, INC. (US) 2014-04-10 WO disclosed
EP-2694480-A1 ADAMANTYL COMPOUNDS F.HOFFMANN-LA ROCHE AG (CH) 2014-02-12 EP disclosed
WO-2012136684-A1 ADAMANTYL COMPOUNDS F. HOFFMANN-LA ROCHE AG (CH) 2012-10-11 WO disclosed
EP-2451783-A2 LONIDAMINE ANALOGUES FOR FERTILITY MANAGEMENT University Of Kansas (US) 2012-05-16 EP disclosed
EP-1912935-A2 HIV REVERSE TRANSCRIPTASE INHIBITORS Merck & Co., Inc. (US) 2008-04-23 EP disclosed
WO-2008015269-A1 SUBSTITUTED PYRAZOLOPYRIMIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICINE MERZ PHARMA GMBH & CO. KGAA (DE) 2008-02-07 WO disclosed
EP-1858852-A1 HETEROARYLSULFONYL STILBENES AS 5-HT2A ANTAGONISTS MERCK SHARP & DOHME LTD. (GB) 2007-11-28 EP disclosed
EP-1786424-A2 LONIDAMINE ANALOGUES AND THEIR USE IN MALE CONTRACEPTION AND CANCER TREATMENT The University of Kansas (US) 2007-05-23 EP disclosed
WO-2007038367-A1 INDAZOLES, BENZOTHIAZOLES, BENZOISOTHIAZOLES, BENZISOXAZOLES, PYRAZOLOPYRIDINES, ISOTHIAZOLOPYRIDINES, AND PREPARATION AND USES THEREOF MEMORY PHARMACEUTICALS CORPORATION (US) 2007-04-05 WO disclosed
WO-2007015809-A2 HIV REVERSE TRANSCRIPTASE INHIBITORS MERCK & CO., INC. (US) 2007-02-08 WO disclosed
WO-2006095205-A1 HETEROARYLSULFONYL STILBENES AS 5-HT2A ANTAGONISTS MERCK SHARP & DOHME LIMITED (GB) 2006-09-14 WO disclosed
WO-2006023704-A2 LONIDAMINE ANALOGUES AND THEIR USE IN MALE CONTRACEPTION AND CANCER TREATMENT UNIVERSITY OF KANSAS (US) 2006-03-02 WO disclosed
EP-0620811-A1 HETEROCYCLE-SUBSTITUTED BENZYLAMINE DERIVATIVES AS ANTIRETROVIRAL COMPOUNDS JANSSEN PHARMACEUTICA N.V. (BE) 1994-10-26 EP disclosed
WO-1993013069-A1 HETEROCYCLE-SUBSTITUTED BENZYLAMINE DERIVATIVES AS ANTIRETROVIRAL COMPOUNDS JANSSEN PHARMACEUTICA N.V. (BE) 1993-07-08 WO disclosed