⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19836838 | 1.00 | — | — | |
| SCHEMBL6051868 | 0.93 | CYP2C19 (0.36) | — | |
| SCHEMBL2630682 | 0.91 | — | — | |
| SCHEMBL4745112 | 0.88 | LMNA (0.32) | — | |
| SCHEMBL17766693 | 0.88 | LMNA (0.32) | — | |
| SCHEMBL4745076 | 0.88 | LMNA (0.32) | — | |
| SCHEMBL17766691 | 0.88 | LMNA (0.32) | — | |
| SCHEMBL4746164 | 0.88 | LMNA (0.32) | — | |
| SCHEMBL14548641 | 0.87 | CYP2C19 (0.36) | — | |
| SCHEMBL16781965 | 0.80 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021138537-A1 | CHEMICALLY MODIFIED OLIGONUCLEOTIDES WITH IMPROVED SYSTEMIC DELIVERY | PHIO PHARMACEUTICALS CORP. (US) | 2021-07-08 | — | — | WO | disclosed |
| US-10184124-B2 | RNA interference in ocular indications | PHIO PHARMACEUTICALS CORP. (US) | 2019-01-22 | — | — | US | disclosed |
| US-9636643-B2 | Polymeric matrices formed from monomers comprising a protected amine group | GENERAL ELECTRIC COMPANY (US) | 2017-05-02 | — | — | US | disclosed |
| US-20160130578-A1 | REDUCED SIZE SELF-DELIVERING RNAI COMPOUNDS | PHIO PHARMACEUTICALS CORP. | 2016-05-12 | — | — | US | disclosed |
| US-20120152839-A1 | MODIFIED SULFONAMIDE POLYMERIC MATRICES | BL TECHNOLOGIES, INC. | 2012-06-21 | — | — | US | disclosed |