SCHEMBL9966870

SCHEMBL9966870

Cc1cccc(C)c1-c1cccc(COc2ccc(C(N)=O)cc2)c1

nearest known ligand 0.68

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
FFAR1 O14842 14/20 0.68
GNA15 P30679 1/20 0.64
PARP10 Q53GL7 5/20 0.64
MAOB P27338 2/20 0.64
PARP15 Q460N3 1/20 0.64
PARP14 Q460N5 1/20 0.64
FFAR4 Q5NUL3 1/20 0.58

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12577973 0.90 MAOB (0.69) FFAR1GNA15MAOBFFAR4
SCHEMBL9966869 0.90 FFAR1 (0.72) FFAR1GNA15FFAR4
SCHEMBL15494695 0.84 FFAR1 (0.77) FFAR1GNA15
SCHEMBL9934278 0.83 FFAR1 (0.83) FFAR1GNA15FFAR4
SCHEMBL15153440 0.82 FFAR1 (0.64) FFAR1GNA15MAOBFFAR4
SCHEMBL1635007 0.81 FFAR1 (1.00) FFAR1FFAR4
SCHEMBL9935151 0.80 FFAR1 (1.00) FFAR1GNA15
SCHEMBL12640903 0.80 FFAR1 (0.62) FFAR1GNA15FFAR4
SCHEMBL28512730 0.80 PARP10 (0.55) FFAR1PARP10MAOBPARP15PARP14
SCHEMBL15485443 0.79 FFAR1 (0.68) FFAR1GNA15FFAR4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20120157459-A1 NOVEL 3-HYDROXY-5-ARYLISOTHIAZOLE DERIVATIVE MOCHIDA PHARMACEUTICAL CO., LTD. (JP) 2012-06-21 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120157459-A1 NOVEL 3-HYDROXY-5-ARYLISOTHIAZOLE DERIVATIVE GPR119, GPR27, NR0B1 FFAR1 39/4885GNA15 667/4885PARP10 1690/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.