Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LYN | P07948 | 8/20 | 0.47 |
| ▸ | LCK | P06239 | 7/20 | 0.47 |
| ▸ | INSR | P06213 | 6/20 | 0.47 |
| ▸ | SRC | P12931 | 6/20 | 0.47 |
| ▸ | KDR | P35968 | 6/20 | 0.47 |
| ▸ | HCK | P08631 | 3/20 | 0.47 |
| ▸ | BRAF | P15056 | 5/20 | 0.40 |
| ▸ | ABL1 | P00519 | 5/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.39 |
| ▸ | KIT | P10721 | 2/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.37 |
| ▸ | BCR | P11274 | 2/20 | 0.37 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.37 |
| ▸ | FYN | P06241 | 1/20 | 0.37 |
| ▸ | RET | P07949 | 1/20 | 0.37 |
| ▸ | ARAF | P10398 | 1/20 | 0.37 |
| ▸ | NQO2 | P16083 | 1/20 | 0.37 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.37 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3586049 | 0.92 | LCK (0.56) | LYNLCKINSRSRCKDR | |
| SCHEMBL9970880 | 0.92 | LCK (0.56) | LYNLCKINSRSRCKDR | |
| SCHEMBL9967469 | 0.88 | INSR (0.47) | LYNLCKINSRSRCKDR | |
| SCHEMBL9967471 | 0.87 | INSR (0.49) | LYNLCKINSRSRCKDR | |
| SCHEMBL13503060 | 0.86 | LCK (0.47) | LYNLCKINSRSRCKDR | |
| SCHEMBL9967470 | 0.86 | INSR (0.52) | LYNLCKINSRSRCKDR | |
| SCHEMBL9967453 | 0.86 | INSR (0.51) | LYNLCKINSRSRCKDR | |
| SCHEMBL9967454 | 0.84 | LCK (0.49) | LYNLCKINSRSRCKDR | |
| SCHEMBL9967455 | 0.83 | LCK (0.51) | LYNLCKINSRSRCKDR | |
| SCHEMBL9967457 | 0.83 | LCK (0.48) | LYNLCKINSRSRCKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8202876-B2 | Compounds and compositions as protein kinase inhibitors | IRM LLC (BM) | 2012-06-19 | — | — | US | disclosed |