Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN11 | Q06124 | 1/20 | 0.42 |
| ▸ | HTR6 | P50406 | 2/20 | 0.41 |
| ▸ | PDE4A | P27815 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | HTR7 | P34969 | 1/20 | 0.41 |
| ▸ | HRH1 | P35367 | 1/20 | 0.41 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18053332 | 0.88 | HTR6 (0.44) | PTPN11HTR6PDE4APDE4BPDE4C | |
| SCHEMBL29604791 | 0.87 | CA1 (0.46) | PTPN11HTR6L3MBTL1CYP3A4POLB | |
| SCHEMBL16884156 | 0.87 | PTPN11 (0.41) | PTPN11L3MBTL1POLBALDH3A1HTT | |
| SCHEMBL20846089 | 0.87 | BRD4 (0.51) | PTPN11L3MBTL1POLBALDH3A1HTT | |
| SCHEMBL14685251 | 0.87 | CA1 (0.46) | PTPN11HTR6L3MBTL1CYP3A4POLB | |
| SCHEMBL14883425 | 0.84 | CYP3A4 (0.54) | PTPN11HTR6PDE4APDE4BPDE4C | |
| SCHEMBL15882765 | 0.84 | ENPP3 (0.44) | PTPN11HTR6PDE4APDE4BPDE4C | |
| Potassium Ion SCHEMBL20548099 | 0.84 | PTPN11 (0.39) | PTPN11HTR6L3MBTL1POLBALDH3A1 | |
| Boric Acid SCHEMBL28547119 | 0.84 | PTPN11 (0.41) | PTPN11HTR6PDE4APDE4BPDE4C | |
| SCHEMBL22838078 | 0.83 | PTPN11 (0.44) | PTPN11HTR6PDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019057660-A1 | INDOLE AND AZAINDOLE COMPOUNDS WITH SUBSTITUTED 6-MEMBERED ARYL AND HETEROARYL RINGS AS AGROCHEMICAL FUNGICIDES | BASF SE (DE) | 2019-03-28 | — | — | WO | disclosed |
| US-10023569-B2 | Methods of preparing inhibitors of influenza viruses replication | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2018-07-17 | — | — | US | disclosed |
| WO-2016183116-A1 | METHODS OF PREPARING INHIBITORS OF INFLUENZA VIRUSES REPLICATION | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2016-11-17 | — | — | WO | disclosed |
| US-20160251354-A1 | METHODS OF PREPARING INHIBITORS OF INFLUENZA VIRUSES REPLICATION | VERTEX PHARMACEUTICALS INCORPORATED | 2016-09-01 | — | — | US | disclosed |
| WO-2012083122-A1 | INHIBITORS OF INFLUENZA VIRUSES REPLICATION | VERTEX PHARMACEUTICAL INCORPORATED (US) | 2012-06-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10023569-B2 | Methods of preparing inhibitors of influenza viruses replication | ZC3HAV1, ZC3HAV1L, POLR2H | PTPN11 1607/4885HTR6 4164/4885PDE4A 772/4885 |
| US-20160251354-A1 | METHODS OF PREPARING INHIBITORS OF INFLUENZA VIRUSES REPLICATION | ZC3HAV1, ZC3HAV1L, POLR2H | PTPN11 1607/4885HTR6 4164/4885PDE4A 772/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.