SCHEMBL9968151

SCHEMBL9968151

CC(C)c1cc2c3cnc([Si](c4ccccc4)(c4ccccc4)c4cc5c(cn4)c4cc(C(C)C)ncc4n5-c4ccccc4)cc3n(-c3ccccc3)c2cn1

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.36
GAA P10253 1/20 0.36
PLK1 P53350 2/20 0.32
CDK4 P11802 1/20 0.31
CDK6 Q00534 1/20 0.31
KDM4E B2RXH2 1/20 0.31
ATM Q13315 1/20 0.31
L3MBTL1 Q9Y468 1/20 0.31
TSHR P16473 2/20 0.31
NPC1 O15118 1/20 0.30
LMNA P02545 1/20 0.30
TP53 P04637 1/20 0.30
HPGD P15428 1/20 0.30
RAB9A P51151 1/20 0.30
SMN1; SMN2 Q16637 1/20 0.30
HSD17B10 Q99714 1/20 0.30
MAPK13 O15264 1/20 0.30
MAPK12 P53778 1/20 0.30
MAPK11 Q15759 1/20 0.30
MAPK14 Q16539 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9968051 0.81 KDM4E (0.42) ALDH1A1GAAPLK1CDK4CDK6
SCHEMBL9968055 0.77 CDK4 (0.49) CDK4CDK6KDM4EATML3MBTL1
SCHEMBL9968137 0.75 CYP1A2 (0.34) ALDH1A1GAAPLK1KDM4EATM
SCHEMBL9968178 0.74 CDK4 (0.44) CDK4CDK6KDM4EATML3MBTL1
SCHEMBL17463373 0.71 L3MBTL1 (0.47) ALDH1A1CDK4CDK6KDM4EATM
SCHEMBL17463354 0.70 L3MBTL1 (0.46) ALDH1A1KDM4EATML3MBTL1TSHR
SCHEMBL17463377 0.68 CDK4 (0.37) ALDH1A1CDK4CDK6KDM4EATM
SCHEMBL17463360 0.68 CDK4 (0.41) CDK4CDK6KDM4EATML3MBTL1
SCHEMBL9968173 0.67 MAT2A (0.35) CDK4CDK6
SCHEMBL9968054 0.65 CDK4 (0.40) ALDH1A1CDK4CDK6KDM4EATM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20120153817-A1 ORGANIC ELECTROLUMINESCENCE DEVICE FUJIFILM CORPORATION (JP) 2012-06-21 US disclosed
US-20120153817-A1 ORGANIC ELECTROLUMINESCENCE DEVICE FUJIFILM CORPORATION (JP) 2012-06-21 US disclosed