Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.46 |
| ▸ | SMO | Q99835 | 10/20 | 0.42 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 2/20 | 0.38 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.38 |
| ▸ | INSR | P06213 | 1/20 | 0.38 |
| ▸ | IGF1R | P08069 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9968394 | 0.93 | PDE10A (0.41) | PDE10ASMOCYP2C9 | |
| SCHEMBL9931941 | 0.91 | OPRM1 (0.44) | SMOCYP2C9HRH3MCHR1 | |
| SCHEMBL9932360 | 0.91 | MAP4K4 (0.44) | SMOCYP2C9HRH3MCHR1 | |
| SCHEMBL9931455 | 0.90 | SMO (0.40) | SMOCYP2C9HRH3MCHR1 | |
| SCHEMBL9932043 | 0.85 | SMO (0.42) | SMOCYP2C9 | |
| SCHEMBL9932767 | 0.84 | PDE10A (0.44) | PDE10ASMO | |
| SCHEMBL9931893 | 0.83 | MEN1 (0.41) | PDE10ASMOCYP2C9 | |
| SCHEMBL9932415 | 0.83 | PDE10A (0.42) | PDE10ASMOCYP2C9 | |
| SCHEMBL9968509 | 0.83 | SMO (0.57) | PDE10ASMO | |
| SCHEMBL9933208 | 0.83 | CYP2C9 (0.41) | PDE10ASMOCYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120157471-A1 | BENZIMIDAZOLE DERIVATIVES | PFIZER INC. (US) | 2012-06-21 | — | — | US | disclosed |
| US-20120157471-A1 | BENZIMIDAZOLE DERIVATIVES | PFIZER INC. (US) | 2012-06-21 | — | — | US | disclosed |
| WO-2011027249-A2 | BENZIMIDAZOLE DERIVATIVES | PFIZER INC. (US) | 2011-03-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120157471-A1 | BENZIMIDAZOLE DERIVATIVES | SMO, RB1, GLI1 | PDE10A 1879/4885SMO 1/4885AAK1 4405/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.