Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3A | P46098 | 8/20 | 0.51 |
| ▸ | HTR3B | O95264 | 5/20 | 0.51 |
| ▸ | HRH4 | Q9H3N8 | 5/20 | 0.51 |
| ▸ | HTR3E | A5X5Y0 | 4/20 | 0.51 |
| ▸ | HTR3D | Q70Z44 | 4/20 | 0.51 |
| ▸ | HTR3C | Q8WXA8 | 4/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | THPO | P40225 | 1/20 | 0.51 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9932793 | 0.88 | KDM4E (0.42) | HTR3AHTR3BHRH4HTR3EHTR3D | |
| SCHEMBL9968415 | 0.88 | MEN1 (0.41) | HTR3AHTR3BHRH4HTR3EHTR3D | |
| SCHEMBL9968519 | 0.88 | HTR3A (0.49) | HTR3AHTR3BHTR3EHTR3DHTR3C | |
| SCHEMBL9968416 | 0.87 | TSHR (0.43) | KDM4EALDH1A1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL9931839 | 0.86 | MEN1 (0.46) | KDM4EALDH1A1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL9968419 | 0.86 | MEN1 (0.41) | HTR3AHTR3BHRH4HTR3EHTR3D | |
| SCHEMBL9932626 | 0.86 | HSD11B1 (0.48) | ALDH1A1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL12841110 | 0.86 | KDM4E (0.40) | HTR3AHTR3BHRH4HTR3EHTR3D | |
| SCHEMBL9932543 | 0.86 | SMO (0.45) | KDM4EALDH1A1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL9968414 | 0.84 | HSD11B1 (0.47) | ALDH1A1KMT2AMEN1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120157471-A1 | BENZIMIDAZOLE DERIVATIVES | PFIZER INC. (US) | 2012-06-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120157471-A1 | BENZIMIDAZOLE DERIVATIVES | SMO, RB1, GLI1 | HTR3A 3518/4885HTR3B 2683/4885HRH4 113/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.