Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARA | P10276 | 5/20 | 0.74 |
| ▸ | RARB | P10826 | 5/20 | 0.74 |
| ▸ | RARG | P13631 | 5/20 | 0.74 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.74 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.74 |
| ▸ | CYP26A1 | O43174 | 2/20 | 0.55 |
| ▸ | CRABP2 | P29373 | 1/20 | 0.36 |
| ▸ | GRM5 | P41594 | 5/20 | 0.34 |
| ▸ | BACE1 | P56817 | 4/20 | 0.33 |
| ▸ | BACE2 | Q9Y5Z0 | 3/20 | 0.33 |
| ▸ | ACACB | O00763 | 1/20 | 0.33 |
| ▸ | MMP13 | P45452 | 1/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.32 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.32 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8630933 | 0.92 | RARA (0.75) | RARARARBRARGCYP3A4KMT2A | |
| SCHEMBL8865753 | 0.91 | RARA (0.74) | RARARARBRARGCYP3A4KMT2A | |
| SCHEMBL996873 | 0.86 | CYP3A4 (0.70) | RARARARBRARGCYP3A4KMT2A | |
| Tazarotene SCHEMBL29512592 | 0.85 | RARA (1.00) | RARARARBRARGCYP3A4KMT2A | |
| Tazarotene SCHEMBL29397163 | 0.85 | RARA (1.00) | RARARARBRARGCYP3A4KMT2A | |
| Tazarotene SCHEMBL5747908 | 0.85 | RARA (1.00) | RARARARBRARGCYP3A4KMT2A | |
| Tazarotene SCHEMBL3134 | 0.85 | RARA (1.00) | RARARARBRARGCYP3A4KMT2A | |
| Tazarotene SCHEMBL6101987 | 0.84 | RARA (0.98) | RARARARBRARGCYP3A4KMT2A | |
| SCHEMBL9334980 | 0.84 | RARA (0.67) | RARARARBRARGCYP3A4KMT2A | |
| SCHEMBL9270697 | 0.83 | CYP3A4 (0.77) | RARARARBRARGCYP3A4KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2453746-A1 | TAZAROTENE DERIVATIVES | Stiefel Laboratories, Inc. (US) | 2012-05-23 | — | — | EP | disclosed |
| WO-2011009023-A1 | TAZAROTENE DERIVATIVES | STIEFEL LABORATORIES, INC. (US) | 2011-01-20 | — | — | WO | disclosed |