Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14361724 | 1.00 | ALDH1A1 (0.36) | ALDH1A1MAPTMCL1ATM | |
| SCHEMBL14361721 | 1.00 | ALDH1A1 (0.36) | ALDH1A1MAPTMCL1ATM | |
| SCHEMBL9944591 | 0.77 | MAPT (0.39) | ALDH1A1MAPTMCL1ATM | |
| SCHEMBL17617312 | 0.65 | ALDH1A1 (0.36) | ALDH1A1MAPTMCL1ATM | |
| SCHEMBL4657978 | 0.59 | ATM (0.50) | ALDH1A1MAPTMCL1ATM | |
| SCHEMBL21942421 | 0.56 | — | — | |
| SCHEMBL4305888 | 0.56 | MAPT (0.40) | ALDH1A1MAPTMCL1ATM | |
| SCHEMBL3215431 | 0.56 | ALDH1A1 (0.40) | ALDH1A1MAPTMCL1ATM | |
| SCHEMBL1425285 | 0.55 | RXRB (0.40) | ALDH1A1MAPT | |
| SCHEMBL7903760 | 0.55 | ALDH1A1 (0.39) | ALDH1A1MAPTMCL1ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120252747-A1 | MACROCYCLIC COMPOUNDS AND METHODS OF MAKING AND USING THE SAME | SILICON VALLEY BANK | 2012-10-04 | — | — | US | disclosed |
| US-8202843-B2 | Macrocyclic compounds and methods of making and using the same | RIB-X PHARMACEUTICALS, INC. (US) | 2012-06-19 | — | — | US | disclosed |
| US-20080045585-A1 | Macrocyclic Compounds And Methods Of Making And Using The Same | BioVersys AG (CH) | 2008-02-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120252747-A1 | MACROCYCLIC COMPOUNDS AND METHODS OF MAKING AND USING THE SAME | CCNO, PTGDR, CCNE1 | ALDH1A1 2970/4885MAPT 4552/4885MCL1 219/4885 |
| US-20080045585-A1 | Macrocyclic Compounds And Methods Of Making And Using The Same | VIP, PROKR1, PGC | ALDH1A1 3986/4885MAPT 4336/4885MCL1 51/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.