PGC — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL2929261	1.00	2/20
SCHEMBL2929264	1.00	2/20
SCHEMBL2936505	1.00	2/20
SCHEMBL2936960	1.00	2/20
SCHEMBL2930150	0.83	2/20
SCHEMBL2930151	0.83	2/20
SCHEMBL2930930	0.73	2/20
SCHEMBL2930932	0.73	2/20
SCHEMBL2931369	0.72	2/20
SCHEMBL2931370	0.72	2/20
SCHEMBL2931630	0.72	2/20
SCHEMBL2936512	0.69	2/20
SCHEMBL2936515	0.69	2/20
SCHEMBL7320800	0.67	2/20
SCHEMBL2934847	0.67	2/20
SCHEMBL2934849	0.67	2/20
SCHEMBL2936533	0.67	2/20
SCHEMBL2936535	0.67	2/20
SCHEMBL2931103	0.66	2/20
SCHEMBL2931105	0.66	2/20

Clinical trials — most relevant to PGC by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Effect of Cardiac Resynchronization Therapy (CRT) on Skeletal Muscle Histology, Neuroendocrine Activation and Inflammatory Response	PHASE4	COMPLETED
GLP-1 Receptor Agonists in Non-diabetic Patients With Psoriatic Arthritis	PHASE4	NOT_YET_RECRUITING
Chronic Cold Acclimation Stimulates the Browning of Subcutaneous White Adipose in Patients With Type 2 Diabetes Mellitus	PHASE4	UNKNOWN
Efficacy of Alogliptin and Pioglitazone in Subjects With Type 2 Diabetes Mellitus	PHASE3	COMPLETED
Efficacy Study of Pioglitazone Compared to Glimepiride on Coronary Atherosclerotic Disease Progression in Subjects With Type 2 Diabetes Mellitus	PHASE3	COMPLETED
Cinnamomum Cassia Effect on IGF1 and Metabolic Control in Patients With DM2 Without Glycemic Control Metformin Treated	PHASE3	COMPLETED
A Study of Bezafibrate in Mitochondrial Myopathy	PHASE2	COMPLETED
Efficacy of SYR-472 in Subjects With Type 2 Diabetes Mellitus	PHASE2	COMPLETED
Effect of Molecular Hydrogen in Patients With NAFLD	nan	COMPLETED
Abnormalities in the Effects of Insulin and Exercise on Glucose- and Lipid Metabolism in Obesity and Type 2 Diabetes	nan	COMPLETED
Individually Tailored Strategies for the Precision Prevention of Gastric Cancer and Colorectal Cancer in the Community	nan	ENROLLING_BY_INVITATION
Dietary Carbohydrate and GERD in Veterans	nan	COMPLETED
Endoscopic Gastric Mucosal Devitalization (GMD) as a Primary Obesity Therapy - Part 2	nan	COMPLETED
Clinical Study to Evaluate Safety and Efficacy of Amino Acid in Healthy Individuals	nan	COMPLETED
Study of the Molecular Basis in the Pathophysiology of Food Intake and Growth in Children	nan	COMPLETED
Effects of an Amino Acid-Based hGH Secretagogue on Triiodythyronine	nan	COMPLETED
Endoscopic Gastric Mucosal Devitalization (GMD) as a Primary Obesity Therapy	nan	COMPLETED
The Importance of Ghrelin for Glucose Metabolism After Sleeve Gastrectomy	nan	COMPLETED
Cold Stress Stimulate the Browing of Subcutaneous White Adipose in Healthy Adults	nan	COMPLETED
Effect of Liraglutide on Clock Genes	nan	UNKNOWN
Effect of Exercise on Irisin Levels of Hypothyroid Rats	nan	COMPLETED
Macronutrient Regulation of Ghrelin and Peptide YY	nan	COMPLETED
The Effect of Pharmacological Antilipolysis on the Metabolic Effects of Ghrelin	nan	COMPLETED
Purinergic Signaling and the Postmenopausal Heart	nan	RECRUITING
Microbiome Analysis in Gastric Intestinal Metaplasia and in Gastric Cancer and Subtypes Correlation	nan	UNKNOWN
The Effects of TZD on Fat Metabolism and Insulin Sensitivity in GH-Replaced GHD Patients	nan	COMPLETED
Ghrelin and Gastric Emptying in Children With Functional Dyspepsia	nan	COMPLETED
Study IL- 35 Level and Fibronectin Type Ⅲ Domain Containing Protein 5 \ Irsin (FNDC5 rs3480) Gene Variations in Chronic Hepatitis B.	nan	UNKNOWN
Metabolic Flexibility in Patients With Early Triple-negative Breast Cancer	nan	ACTIVE_NOT_RECRUITING
Serum Irisin Levels in Obese Children	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a PGC binder may also engage these)

Protein	Name	Similarity
Q9N2D3	—	1.000	Q9N2D3 →
P03955	—	1.000	P03955 →
Q9GMY4	—	0.999	Q9GMY4 →
Q9GMY3	—	0.998	Q9GMY3 →
Q9D7R7	—	0.994	Q9D7R7 →
P81498	—	0.994	P81498 →
P04073	—	0.993	P04073 →
Q689Z7	—	0.991	Q689Z7 →
Q9N2D4	—	0.988	Q9N2D4 →
Q9GMY6	—	0.988	Q9GMY6 →
Q9GMY8	—	0.987	Q9GMY8 →
P81497	—	0.987	P81497 →
Q9GMY7	—	0.987	Q9GMY7 →
P0DJD7	—	0.984	P0DJD7 →
P0DJD8	—	0.984	P0DJD8 →
Q8SQ41	—	0.984	Q8SQ41 →
PGA5	Pepsin A	0.984	landscape →
Q9GMY2	—	0.983	Q9GMY2 →
P16476	—	0.983	P16476 →
P27677	—	0.982	P27677 →
CTSE	Cathepsin E	0.982	landscape →
P03954	—	0.981	P03954 →
P00792	—	0.980	P00792 →
P27678	—	0.980	P27678 →
P11489	—	0.980	P11489 →
Q64411	—	0.980	Q64411 →
Q9N2D2	—	0.979	Q9N2D2 →
P27822	—	0.979	P27822 →
P70269	—	0.977	P70269 →
P28712	—	0.977	P28712 →