SCHEMBL997046

SCHEMBL997046

C=CC(=O)c1ccc2c(c1)OCS2

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 5/20 0.42
KMT2A Q03164 4/20 0.42
ALDH1A1 P00352 4/20 0.42
MEN1 O00255 3/20 0.42
SMN1; SMN2 Q16637 3/20 0.42
HPGD P15428 2/20 0.42
MAPK1 P28482 2/20 0.42
KDM4E B2RXH2 1/20 0.42
EGFR P00533 1/20 0.42
TP53 P04637 1/20 0.42
CYP3A4 P08684 1/20 0.42
PKM P14618 1/20 0.42
ALOX15 P16050 1/20 0.42
ALOX12 P18054 1/20 0.42
JAK1 P23458 1/20 0.42
HSD17B10 Q99714 1/20 0.42
TDP1 Q9NUW8 1/20 0.42
ALDH5A1 P51649 1/20 0.41
ABAT P80404 1/20 0.41
AKT1 P31749 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL997040 0.88 MAPT (0.42) MAPTKMT2AALDH1A1MEN1SMN1; SMN2
SCHEMBL997623 0.86 CTNNB1 (0.46) MAPTKMT2AALDH1A1MEN1SMN1; SMN2
SCHEMBL997528 0.76 CTNNB1 (0.58) MAPTKMT2AALDH1A1MEN1SMN1; SMN2
SCHEMBL999704 0.73 TSHR (0.61) MAPTKMT2AALDH1A1MEN1SMN1; SMN2
SCHEMBL29383324 0.73 TSHR (0.61) MAPTKMT2AALDH1A1MEN1SMN1; SMN2
SCHEMBL998638 0.73 ALDH1A1 (0.62) MAPTKMT2AALDH1A1MEN1SMN1; SMN2
SCHEMBL22001284 0.71 MEN1 (0.52) MAPTKMT2AALDH1A1MEN1SMN1; SMN2
SCHEMBL20710940 0.69 PPARA (0.59) MAPTTUBB4ATUBBTUBA3CTUBA1B
SCHEMBL20893486 0.69 CYP3A4 (0.47) MAPTMAPK1CYP3A4TUBB4ATUBB
SCHEMBL5546100 0.69 TUBB4A (0.33) TUBB4ATUBBTUBA3CTUBA1BTUBA4A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2011009826-A2 NOVEL CHALCONE DERIVATIVES WITH CYTOTOXIC ACTIVITY ADAMED Sp.z o.o. (PL) 2011-01-27 WO disclosed