Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 19/20 | 0.67 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4534690 | 0.83 | LRRK2 (0.67) | LRRK2MAPK1CYP1A2 | |
| SCHEMBL4560592 | 0.80 | LRRK2 (0.62) | LRRK2MAPK1CYP1A2 | |
| SCHEMBL5021115 | 0.80 | LRRK2 (1.00) | LRRK2CYP1A2 | |
| SCHEMBL18765835 | 0.72 | MAPK1 (0.62) | LRRK2MAPK1CYP1A2 | |
| SCHEMBL5021214 | 0.72 | MAPK1 (0.54) | LRRK2MAPK1CYP1A2 | |
| SCHEMBL4538455 | 0.72 | MAPK1 (0.54) | LRRK2MAPK1CYP1A2 | |
| SCHEMBL18765584 | 0.71 | MAPK1 (0.60) | LRRK2MAPK1CYP1A2 | |
| SCHEMBL29676695 | 0.71 | MAPK1 (0.60) | LRRK2MAPK1CYP1A2 | |
| SCHEMBL22300598 | 0.71 | MAPK1 (0.75) | LRRK2MAPK1CYP1A2 | |
| SCHEMBL16814061 | 0.71 | MAPK1 (0.59) | LRRK2MAPK1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120157427-A1 | PYRAZOLE AMINOPYRIMIDINE DERIVATIVES AS LRRK2 MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2012-06-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120157427-A1 | PYRAZOLE AMINOPYRIMIDINE DERIVATIVES AS LRRK2 MODULATORS | LRRK2, PARK7, PINK1 | LRRK2 1/4885MAPK1 391/4885CYP1A2 3177/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.