Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 7/20 | 0.50 |
| ▸ | ABCB1 | P08183 | 8/20 | 0.40 |
| ▸ | ABCG2 | Q9UNQ0 | 8/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | STAT3 | P40763 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL997606 | 0.98 | KIF11 (0.50) | KIF11ABCB1ABCG2TP53LMNA | |
| SCHEMBL999416 | 0.96 | KIF11 (0.52) | KIF11ABCB1ABCG2TP53LMNA | |
| SCHEMBL997890 | 0.90 | KIF11 (0.49) | KIF11ABCB1ABCG2TP53LMNA | |
| SCHEMBL2035529 | 0.88 | KIF11 (0.47) | KIF11ABCB1ABCG2TP53MAPT | |
| SCHEMBL2033145 | 0.88 | KIF11 (0.43) | KIF11ABCB1ABCG2TP53LMNA | |
| SCHEMBL996837 | 0.87 | ABCG2 (0.50) | KIF11ABCB1ABCG2TP53LMNA | |
| SCHEMBL998933 | 0.87 | KIF11 (0.53) | KIF11ABCB1ABCG2TP53LMNA | |
| SCHEMBL2032121 | 0.86 | KIF11 (0.42) | KIF11ABCB1ABCG2TP53LMNA | |
| SCHEMBL999146 | 0.85 | KIF11 (0.43) | KIF11ABCB1ABCG2TP53LMNA | |
| SCHEMBL2034973 | 0.85 | KIF11 (0.43) | KIF11ABCB1ABCG2TP53LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1637521-B1 | NOVEL TRICYCLIC HETEROCYCLE COMPOUND | ONO PHARMACEUTICAL CO (JP) | 2013-06-19 | — | — | EP | claimed |
| US-7872133-B2 | Tricyclic heterocycle compound | ONO PHARMACEUTICAL CO., LTD. (JP) | 2011-01-18 | — | — | US | disclosed |