Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCG2 | Q9UNQ0 | 3/20 | 0.50 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.50 |
| ▸ | KIF11 | P52732 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 4/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL999416 | 0.91 | KIF11 (0.52) | ABCG2ABCB1KIF11MAPTLMNA | |
| SCHEMBL997890 | 0.91 | KIF11 (0.49) | ABCG2ABCB1KIF11MAPTNPSR1 | |
| SCHEMBL997546 | 0.90 | ABCG2 (0.53) | ABCG2ABCB1KIF11MAPTLMNA | |
| SCHEMBL1001235 | 0.89 | ABCB1 (0.48) | ABCG2ABCB1MAPTNPSR1MEN1 | |
| SCHEMBL998600 | 0.88 | ABCG2 (0.53) | ABCG2ABCB1KIF11MAPTLMNA | |
| SCHEMBL997606 | 0.87 | KIF11 (0.50) | ABCG2ABCB1KIF11MAPTLMNA | |
| SCHEMBL997180 | 0.87 | KIF11 (0.50) | ABCG2ABCB1KIF11MAPTLMNA | |
| SCHEMBL998542 | 0.87 | KIF11 (0.43) | ABCG2ABCB1KIF11MAPTMEN1 | |
| SCHEMBL997940 | 0.86 | KIF11 (0.44) | ABCG2ABCB1KIF11MAPTNPSR1 | |
| SCHEMBL997417 | 0.86 | ALDH1A1 (0.48) | ABCG2ABCB1KIF11MAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7872133-B2 | Tricyclic heterocycle compound | ONO PHARMACEUTICAL CO., LTD. (JP) | 2011-01-18 | — | — | US | disclosed |
| US-20060154944-A1 | Novel tricyclic heterocycle compound | ONO PHARMACEUTICAL CO., LTD. (JP) | 2006-07-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060154944-A1 | Novel tricyclic heterocycle compound | CYP11B1, CYP11B2, HCCS | ABCG2 309/4885ABCB1 307/4885KIF11 4760/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.